HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: SAE2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
Gene: UBA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 26496610, 28514442, 17353931, 33961781, 23601649, 36652389, 19250909, 9920803, 28165030, 21518904, 31575873, 18691969, 25412743, 12641448, 17643372
Identification Methods affinity chromatography technology, pull down, cross-linking study, enzymatic study, x-ray crystallography, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, nuclear magnetic resonance, sumoylase assay
Interaction Type physical association, direct interaction, association, sumoylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains ThiF~UQ_con, UAE_UbL~UQ_con
Common GO terms GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016925 - protein sumoylation
GO:0044388 - small protein activating enzyme binding
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 158
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024