HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: 2ABB (Q00005)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)
Gene: PPP2R2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	28330616, 33961781, 19156129, 23135275
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Hs			1 443
+	Hs
		915163 PP2AB_HUMAN (1-309): 0: 528: 97.41		2ABB_HUMAN (1-443): 0: 825: 100.00
+	Hs
		931049 PP2AA_HUMAN (1-309): 0: 529: 100.00		2ABG_HUMAN (1-443): 0: 808: 87.13
+	Hs
		915310 PP2AB_HUMAN (1-309): 0: 528: 97.41		2ABG_HUMAN (1-443): 0: 808: 87.13
+	Hs
		890952 PP4C_HUMAN (4-309): 0: 508: 64.82		2ABB_HUMAN (1-443): 0: 825: 100.00
+	Xl
		50761 Q92140_XENLA (1-309): 0: 527: 97.09		2ABB_XENLA (6-443): 0: 801: 93.15
+	Xl
		50750 Q8AVH9_XENLA (1-309): 0: 526: 98.71		2ABB_XENLA (6-443): 0: 801: 93.15
+	Hs
		891015 PP4C_HUMAN (4-309): 0: 508: 64.82		2ABG_HUMAN (1-443): 0: 808: 87.13
+	Hs
		930887 PP2AA_HUMAN (1-309): 0: 529: 100.00		2ABD_HUMAN (21-443): 0: 783: 87.94
+	Hs
		915218 PP2AB_HUMAN (1-309): 0: 528: 97.41		2ABD_HUMAN (21-443): 0: 783: 87.94
+	Hs
		927793 PP2AA_HUMAN (1-309): 0: 529: 100.00		2ABA_HUMAN (19-443): 0: 782: 88.47
+	Hs
		915156 PP2AB_HUMAN (1-309): 0: 528: 97.41		2ABA_HUMAN (19-443): 0: 782: 88.47
+	Mm
		915330 PP2AB_MOUSE (1-309): 0: 528: 97.41		2ABA_MOUSE (19-443): 0: 782: 88.47
+	Xl
		1153591 Q8AVH9_XENLA (1-309): 0: 526: 98.71		Q6IRD3_XENLA (18-443): 0: 770: 86.15
+	Hs
		890977 PP4C_HUMAN (4-309): 0: 508: 64.82		2ABD_HUMAN (21-443): 0: 783: 87.94
+	Hs
		890945 PP4C_HUMAN (4-309): 0: 508: 64.82		2ABA_HUMAN (19-443): 0: 782: 88.47
+	Dm
		619858 PP2A_DROME (1-309): 0: 524: 93.85		2ABA_DROME (19-441): 0: 759: 79.20
+	Ce
		106202 PP2A_CAEEL (3-309): 0: 519: 89.25		2AB1_CAEEL (17-440): 0: 678: 65.07
+	Sp
		619316 PP2A2_SCHPO (5-309): 0: 504: 79.02		2ABA_SCHPO (1-439): 0: 644: 54.64
+	Sc
		618793 PP2A1_YEAST (10-309): 0: 517: 76.00		2ABA_YEAST (20-367): 0: 550: 57.14
+	Sc
		618856 PP2A2_YEAST (10-309): 0: 514: 76.67		2ABA_YEAST (20-367): 0: 550: 57.14