HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	27563096, 18160256
Identification Methods	affinity chromatography technology, pull down, phosphatase assay
Interaction Type	physical association, direct interaction, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane GO:0035556 - intracellular signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 309 Hs			1 479
+	Mm
		682104 PP2AA_MOUSE (1-309): 0: 528: 99.68		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Hs
		682162 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Hs
		681777 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Mm
		682103 PP1A_MOUSE (5-296): 0: 504: 46.84		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Hs
		681698 PP1G_HUMAN (7-306): 0: 505: 45.96		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		681767 PP1A_HUMAN (5-296): 0: 504: 46.51		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Dm
		619883 PP2A_DROME (1-309): 0: 524: 93.85		AKT1_DROME (3-473): 0: 527: 62.50
+	Hs
		931029 PP2AA_HUMAN (1-309): 0: 529: 100.00		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		116996 PP2AA_HUMAN (1-309): 0: 529: 100.00		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		408588 PP1A_HUMAN (5-296): 0: 504: 46.51		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Sp
		619319 PP2A2_SCHPO (5-309): 0: 504: 79.02		GAD8_SCHPO (121-477): 6.91e-146: 430: 41.74