HitPredict

Interactor 1: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.562

Property	Details
Experiments	unassigned1853, 24275654
Identification Methods	anti tag coimmunoprecipitation, two hybrid
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 2527
+	Hs
		1037252 TBB3_HUMAN (1-443): 0: 714: 93.23		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		428247 TBB5_HUMAN (1-429): 0: 711: 98.37		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130537 TBB2B_HUMAN (1-430): 0: 710: 98.14		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1046482 TBB2A_HUMAN (1-430): 0: 707: 97.67		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130529 TBB6_HUMAN (1-432): 0: 706: 92.36		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		381221 TBB4A_HUMAN (1-427): 0: 706: 98.60		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		1130127 TBB4A_MOUSE (1-427): 0: 706: 98.60		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		1037439 TBB3_HUMAN (1-443): 0: 714: 93.23		SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27
+	Hs
		428238 TBB5_HUMAN (1-429): 0: 711: 98.37		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		933832 TBB4B_HUMAN (1-427): 0: 711: 100.00		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		201179 TBB5_HUMAN (1-429): 0: 711: 98.37		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201419 TBB2B_HUMAN (1-430): 0: 710: 98.14		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201171 TBB4A_HUMAN (1-427): 0: 706: 98.60		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83