Protein: DDHD2
Triacylglycerol hydrolase DDHD2 (TAG hydrolase) (EC 3.1.1.3) (DDHD domain-containing protein 2) (KIAA0725p) (Phospholipase DDHD2) (EC 3.1.1.-) (SAM, WWE and DDHD domain-containing protein 1) (Triglyceride hydrolase DDHD2) (Triglyceride lipase)

Gene: DDHD2
Organism: Homo sapiens
Interactions: 44
UniProt ID: O94830

Gene Ontology (top 5):
GO:0000266 - mitochondrial fission
GO:0004620 - phospholipase activity
GO:0004806 - triacylglycerol lipase activity
GO:0005737 - cytoplasm
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

318221

S23IP
SEC23-interacting protein

3

1

High-throughput

0.861

High

318196

BIEA
Biliverdin reductase A

3

1

High-throughput

0.667

High

318193

TGM4
Protein-glutamine gamma-glutamyltransferase 4

2

2

High-throughput

0.628

High

318205

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

1

High-throughput

0.628

High

318213

AASD1
Alanyl-tRNA editing protein Aarsd1

2

1

High-throughput

0.628

High

318194

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.618

High

318195

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.618

High

318201

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.618

High

318200

EF1A2
Elongation factor 1-alpha 2

2

1

High-throughput

0.611

High

318188

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

318191

CH3L1
Chitinase-3-like protein 1

2

0

High-throughput

0.602

High

318209

RPGF5
Rap guanine nucleotide exchange factor 5

2

2

High-throughput

0.574

High

64841

RCCD1
RCC1 domain-containing protein 1

1

4

High-throughput

0.536

High

318203

HS905
Putative heat shock protein HSP 90-alpha A5

2

0

High-throughput

0.528

High

318185

ALBU
Albumin

1

0

High-throughput

0.513

High

318187

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

318183

HPT
Haptoglobin

1

1

High-throughput

0.489

High

318186

TRFE
Serotransferrin

1

1

High-throughput

0.489

High

318189

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

318190

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.479

High

318197

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

318198

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.479

High

318206

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

318212

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

318214

DERL1
Derlin-1

1

1

High-throughput

0.479

High

318216

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

318217

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

173803

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

318208

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

318220

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.458

High

318215

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

3

Small-scale

0.445

High

104991

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

139786

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

318199

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.437

High

318204

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

318211

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.426

High

318202

CB068
UPF0561 protein C2orf68

3

0

High-throughput

0.347

High

318219

EMIL1
EMILIN-1

2

0

High-throughput

0.328

High

318182

CERU
Ceruloplasmin

1

0

High-throughput

0.279

Low

318207

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

318218

PCD10
Protocadherin-10

1

0

High-throughput

0.279

Low

318192

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

318210

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

318184

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025