HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	32451438, 35907431, 11252719, 21243721
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 1291
+	Hs
		935251 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		1086320 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		203664 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		935126 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Mm
		952777 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11
+	Hs
		1086279 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98
+	At
		886462 H33_ARATH (1-136): 7.67e-62: 187: 96.32		SUVH4_ARATH (974-1291): 3.06e-63: 229: 18.21
+	Hs
		935204 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Hs
		1086306 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Hs
		935004 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27
+	Hs
		1086228 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27
+	Mm
		101827 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		F8WI37_MOUSE (1060-1290): 1.8e-53: 208: 22.45
+	Hs
		935276 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ASH1L_HUMAN (1075-1290): 1.15e-51: 202: 19.11
+	Hs
		934804 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		1079993 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Mm
		952747 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13
+	Mm
		952754 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		Q6AXH7_MOUSE (1026-1272): 1.64e-48: 188: 13.13
+	Hs
		935270 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT5A_HUMAN (811-916): 4.51e-15: 80.7: 17.39