HitPredict

Interactor 1: RNF4 (P78317)
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
Gene: RNF4

Interactor 2: Q7KZS0 (Q7KZS0)
SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 190 Hs			1 184
+	Hs
		941604 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UB2D4_HUMAN (4-157): 1.13e-74: 222: 31.82
+	Hs
		849306 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		919705 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		895776 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		930135 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		828982 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UBE2A_HUMAN (1-157): 1.19e-68: 207: 36.31
+	Hs
		927745 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UBE2B_HUMAN (1-155): 1.06e-67: 205: 36.13
+	Hs
		941269 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UB2E3_HUMAN (3-156): 2.76e-67: 205: 31.17
+	Hs
		941319 RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00		UB2E2_HUMAN (3-156): 5.39e-67: 205: 31.17
+	Hs
		1089346 LONF1_HUMAN (15-189): 7.63e-31: 119: 18.08		Q7KZS0_HUMAN (1-184): 1.19e-72: 218: 100.00
+	Hs
		930244 LONF1_HUMAN (15-189): 7.63e-31: 119: 18.08		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Zm
		39810 A0A1D6N2L7_MAIZE (13-183): 1.52e-27: 105: 13.98		B4FCQ9_MAIZE (4-157): 1.62e-74: 222: 31.82
+	Hs
		919748 BRE1A_HUMAN (23-190): 2.03e-24: 101: 19.89		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		919747 RN220_HUMAN (70-190): 5.19e-23: 97.1: 23.14		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Dm
		639405 Q9VNJ0_DROME (32-190): 8.82e-24: 97.4: 30.44		UBCD1_DROME (4-157): 1.35e-73: 219: 33.12
+	Hs
		895809 RN220_HUMAN (70-190): 5.19e-23: 97.1: 23.14		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82
+	Hs
		829017 BRE1A_HUMAN (23-190): 2.03e-24: 101: 19.89		UBE2A_HUMAN (1-157): 1.19e-68: 207: 36.31
+	Hs
		927757 BRE1A_HUMAN (23-190): 2.03e-24: 101: 19.89		UBE2B_HUMAN (1-155): 1.06e-67: 205: 36.13
+	Dm
		854575 Q9VNJ0_DROME (32-190): 8.82e-24: 97.4: 30.44		UBCD2_DROME (3-156): 4.79e-67: 206: 31.17
+	Dm
		1181443 Q9VNJ0_DROME (32-190): 8.82e-24: 97.4: 30.44		Q7KNM2_DROME (1-158): 9.6e-65: 197: 75.95