Protein: ZBT21
Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295)

Gene: ZBT21, ZBTB21
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q9ULJ3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1358882

KBTB7
Kelch repeat and BTB domain-containing protein 7

3

1

High-throughput

0.855

High

1380425

ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

2

1

High-throughput

0.811

High

967007

1433G
14-3-3 protein gamma

6

11

High-throughput

0.735

High

691531

1433T
14-3-3 protein theta

5

11

High-throughput

0.716

High

730344

1433B
14-3-3 protein beta/alpha

5

11

High-throughput

0.716

High

1049898

1433F
14-3-3 protein eta

4

11

High-throughput

0.699

High

1047778

NOTC2
Neurogenic locus notch homolog protein 2

1

13

High-throughput

0.691

High

1116621

FHL3
Four and a half LIM domains protein 3

3

4

High-throughput

0.667

High

230676

PRIC3
Prickle planar cell polarity protein 3

2

7

High-throughput

0.628

High

1226751

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

2

2

High-throughput

0.628

High

229374

ZBT14
Zinc finger and BTB domain-containing protein 14

1

20

Small-scale

0.618

High

877038

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.618

High

1025605

CDK16
Cyclin-dependent kinase 16

1

3

High-throughput

0.618

High

1083458

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

2

High-throughput

0.618

High

1114634

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1401336

PASK
PAS domain-containing serine/threonine-protein kinase

1

1

High-throughput

0.618

High

1461585

ZBT21
Zinc finger and BTB domain-containing protein 21

1

5

Small-scale

0.618

High

1461587

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.618

High

972119

1433E
14-3-3 protein epsilon

2

1

High-throughput

0.611

High

990860

1433Z
14-3-3 protein zeta/delta

2

11

High-throughput

0.611

High

1399206

NP1L5
Nucleosome assembly protein 1-like 5

2

1

High-throughput

0.611

High

169281

CASQ2
Calsequestrin-2

3

3

High-throughput

0.609

High

1086194

CETN1
Centrin-1

2

0

High-throughput

0.602

High

163191

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.586

High

1314479

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.586

High

469746

GSTA1
Glutathione S-transferase A1

2

0

High-throughput

0.585

High

1099817

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

0

High-throughput

0.576

High

1459085

FXL17
F-box/LRR-repeat protein 17

1

1

High-throughput

0.575

High

176894

DCLK1
Serine/threonine-protein kinase DCLK1

1

1

High-throughput

0.553

High

245288

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.553

High

1229910

AN34A
Ankyrin repeat domain-containing protein 34A

1

15

High-throughput

0.553

High

1386478

KLH29
Kelch-like protein 29

1

1

High-throughput

0.553

High

1438855

TANC2
Protein TANC2

1

3

High-throughput

0.553

High

1391073

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

407729

S100B
Protein S100-B

1

3

High-throughput

0.536

High

447570

NPM
Nucleophosmin

1

8

High-throughput

0.536

High

593244

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.536

High

1023912

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.536

High

1332577

TEX19
Testis-expressed protein 19

1

1

High-throughput

0.536

High

1129994

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.517

High

387154

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.513

High

920723

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.513

High

940511

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.513

High

960607

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

997561

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.513

High

706348

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

143322

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

247023

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

260602

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

269632

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

11

High-throughput

0.479

High

281454

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

342365

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.479

High

414828

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

474366

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487873

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

520442

ANDR
Androgen receptor

1

11

High-throughput

0.479

High

590014

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

596417

H12
Histone H1.2

1

9

High-throughput

0.479

High

637974

NF1
Neurofibromin

1

2

High-throughput

0.479

High

696844

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

719279

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719385

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

730952

1433S
14-3-3 protein sigma

1

11

High-throughput

0.479

High

769492

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

800163

COIL
Coilin

1

3

High-throughput

0.479

High

834088

HNF4A
Hepatocyte nuclear factor 4-alpha

1

5

High-throughput

0.479

High

851698

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

855539

ATRX
Transcriptional regulator ATRX

1

3

Small-scale

0.479

High

887321

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

936481

AFAD
Afadin

1

4

High-throughput

0.479

High

941088

HDAC4
Histone deacetylase 4

1

6

High-throughput

0.479

High

964508

SUMO2
Small ubiquitin-related modifier 2

1

5

Small-scale

0.479

High

1017294

H33
Histone H3.3

1

8

High-throughput

0.479

High

1037909

HEN1
Helix-loop-helix protein 1

1

3

High-throughput

0.479

High

1045897

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1065783

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

2

High-throughput

0.479

High

1088094

NFIA
Nuclear factor 1 A-type

1

17

High-throughput

0.479

High

1090202

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

High-throughput

0.479

High

1092514

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.479

High

1097626

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1110182

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.479

High

1133731

NFIX
Nuclear factor 1 X-type

1

18

High-throughput

0.479

High

1134083

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

1152062

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.479

High

1198357

CRTC2
CREB-regulated transcription coactivator 2

1

1

High-throughput

0.479

High

1216106

SPD2A
SH3 and PX domain-containing protein 2A

1

2

High-throughput

0.479

High

1219639

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.479

High

1235020

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.479

High

1244844

FBX38
F-box only protein 38

1

1

High-throughput

0.479

High

1248123

CRTC3
CREB-regulated transcription coactivator 3

1

1

High-throughput

0.479

High

1251468

GGYF2
GRB10-interacting GYF protein 2

1

4

High-throughput

0.479

High

1276953

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1277719

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.479

High

1286561

PHLB2
Pleckstrin homology-like domain family B member 2

1

3

High-throughput

0.479

High

1289713

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1309263

KSR1
Kinase suppressor of Ras 1

1

6

High-throughput

0.479

High

1322673

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.479

High

1349484

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1352622

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1352641

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

3

High-throughput

0.479

High

1356780

HDAC7
Histone deacetylase 7

1

6

High-throughput

0.479

High

1360417

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

1401136

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.479

High

1401443

CIC
Protein capicua homolog

1

5

High-throughput

0.479

High

1410266

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1430635

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1437682

PKHA5
Pleckstrin homology domain-containing family A member 5

1

14

High-throughput

0.479

High

1451418

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1459746

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.479

High

1460597

NGAP
Ras GTPase-activating protein nGAP

1

2

High-throughput

0.479

High

1461128

RCOR1
REST corepressor 1

1

4

High-throughput

0.479

High

1461588

BAIP2
BAR/IMD domain-containing adapter protein 2

1

1

High-throughput

0.479

High

1461589

GAB2
GRB2-associated-binding protein 2

1

13

High-throughput

0.479

High

1461590

HDAC5
Histone deacetylase 5

1

6

High-throughput

0.479

High

1461593

STA13
StAR-related lipid transfer protein 13

1

3

High-throughput

0.479

High

1461594

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

165109

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.458

High

252191

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

337409

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.458

High

339119

NADK
NAD kinase

1

0

High-throughput

0.458

High

1245765

LARP1
La-related protein 1

1

0

High-throughput

0.458

High

1256810

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

0

High-throughput

0.458

High

1272894

RFIP2
Rab11 family-interacting protein 2

1

0

High-throughput

0.458

High

1287259

TBCD1
TBC1 domain family member 1

1

0

High-throughput

0.458

High

1387635

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1390426

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1402227

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

1409801

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1410858

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1412892

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1419470

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

1419845

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

1446490

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

1448825

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1451985

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.458

High

1452474

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1452551

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

1454071

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

1458824

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1460941

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1461586

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

1461592

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

911429

IMA5
Importin subunit alpha-5

1

5

High-throughput

0.445

High

1258615

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

106841

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

230591

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.437

High

246185

KIF1B
Kinesin-like protein KIF1B

1

3

High-throughput

0.437

High

1063693

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.437

High

1187147

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

1216036

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.437

High

1257054

SYDE1
Rho GTPase-activating protein SYDE1

1

13

High-throughput

0.437

High

1357444

DEP1B
DEP domain-containing protein 1B

1

13

High-throughput

0.437

High

1447279

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.437

High

1454712

CING
Cingulin

1

1

High-throughput

0.437

High

239248

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

683762

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.279

Low

1326754

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

1461591

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

208756

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.249

Low

991958

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1238321

REEP3
Receptor expression-enhancing protein 3

1

0

High-throughput

0.249

Low

1293250

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

0

High-throughput

0.249

Low

1325148

MILK1
MICAL-like protein 1

1

0

High-throughput

0.249

Low

1338125

NAV1
Neuron navigator 1

1

0

High-throughput

0.249

Low

1339964

O52E2
Olfactory receptor 52E2

1

0

High-throughput

0.249

Low

1383956

DACT3
Dapper homolog 3

1

0

High-throughput

0.249

Low

1429335

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low

1454249

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1461595

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025