Protein: HDAC7
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-)

Gene: HDAC7
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q8WUI4

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001570 - vasculogenesis
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356787

NCOR2
Nuclear receptor corepressor 2

3

20

Small-scale

0.847

High

188324

HDAC3
Histone deacetylase 3

2

17

Small-scale

0.825

High

278392

NCOR1
Nuclear receptor corepressor 1

2

20

Small-scale

0.825

High

1356748

HDAC7
Histone deacetylase 7

2

18

Small-scale

0.768

High

1356750

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.768

High

691278

1433T
14-3-3 protein theta

8

20

Small-scale

0.749

High

1049605

1433F
14-3-3 protein eta

7

20

Small-scale

0.746

High

966667

1433G
14-3-3 protein gamma

6

20

High-throughput

0.734

High

730091

1433B
14-3-3 protein beta/alpha

6

20

Small-scale

0.730

High

1095726

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

5

20

High-throughput

0.720

High

990538

1433Z
14-3-3 protein zeta/delta

5

20

Small-scale

0.716

High

764912

CTNB1
Catenin beta-1

5

20

Small-scale

0.702

High

971824

1433E
14-3-3 protein epsilon

4

12

Small-scale

0.686

High

1034694

MEF2A
Myocyte-specific enhancer factor 2A

4

20

Small-scale

0.680

High

1048934

REL
Proto-oncogene c-Rel

3

20

High-throughput

0.675

High

345205

ZMYM6
Zinc finger MYM-type protein 6

3

8

High-throughput

0.667

High

890212

HINT1
Adenosine 5'-monophosphoramidase HINT1

3

1

High-throughput

0.667

High

1208938

DCA10
DDB1- and CUL4-associated factor 10

3

18

High-throughput

0.667

High

1356755

MOCOS
Molybdenum cofactor sulfurase

3

1

High-throughput

0.667

High

1356768

ADNP
Activity-dependent neuroprotector homeobox protein

3

1

High-throughput

0.667

High

1356782

TTF2
Transcription termination factor 2

3

20

High-throughput

0.667

High

730793

1433S
14-3-3 protein sigma

3

20

Small-scale

0.662

High

363619

EGFR
Epidermal growth factor receptor

3

15

High-throughput

0.656

High

941029

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.647

High

1109932

HDAC1
Histone deacetylase 1

1

18

Small-scale

0.647

High

1356783

HDAC5
Histone deacetylase 5

1

18

Small-scale

0.647

High

1068919

RIPP1
Protein ripply1

3

0

High-throughput

0.646

High

1055026

MEF2C
Myocyte-specific enhancer factor 2C

3

20

Small-scale

0.641

High

1242439

WDR73
Integrator complex assembly factor WDR73

3

0

High-throughput

0.638

High

1356767

ZY11B
Protein zyg-11 homolog B

3

0

High-throughput

0.638

High

962314

RHOA
Transforming protein RhoA

2

8

High-throughput

0.628

High

1161334

HIF1A
Hypoxia-inducible factor 1-alpha

2

11

Small-scale

0.620

High

1356777

KDM5B
Lysine-specific demethylase 5B

1

18

Small-scale

0.618

High

988559

RAC1
Ras-related C3 botulinum toxin substrate 1

2

8

High-throughput

0.615

High

143879

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

4

High-throughput

0.606

High

581194

RAC2
Ras-related C3 botulinum toxin substrate 2

2

8

High-throughput

0.606

High

953583

RAC3
Ras-related C3 botulinum toxin substrate 3

2

8

High-throughput

0.606

High

955415

CDC42
Cell division control protein 42 homolog

2

8

High-throughput

0.606

High

1044684

ARI5A
AT-rich interactive domain-containing protein 5A

2

20

High-throughput

0.606

High

1356749

ACO11
Acyl-coenzyme A thioesterase 11

2

2

High-throughput

0.606

High

1356756

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

8

High-throughput

0.606

High

1356763

KLF16
Krueppel-like factor 16

2

20

High-throughput

0.606

High

1356773

BRWD1
Bromodomain and WD repeat-containing protein 1

2

20

High-throughput

0.606

High

1356760

NRIP2
Nuclear receptor-interacting protein 2

2

0

High-throughput

0.589

High

1164199

UGPA
UTP--glucose-1-phosphate uridylyltransferase

2

0

High-throughput

0.585

High

714293

PML
Protein PML

2

20

Small-scale

0.584

High

937831

FOXA1
Hepatocyte nuclear factor 3-alpha

2

13

Small-scale

0.584

High

223937

LDB2
LIM domain-binding protein 2

2

0

High-throughput

0.580

High

336253

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

2

0

High-throughput

0.580

High

1271980

CENPQ
Centromere protein Q

2

0

High-throughput

0.580

High

1356754

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1356761

MIEN1
Migration and invasion enhancer 1

2

0

High-throughput

0.580

High

224756

ACTN4
Alpha-actinin-4

1

8

Small-scale

0.573

High

1356765

KPCD2
Serine/threonine-protein kinase D2

1

16

Small-scale

0.573

High

692102

MARK3
MAP/microtubule affinity-regulating kinase 3

1

9

Small-scale

0.561

High

832754

BCL6
B-cell lymphoma 6 protein

1

8

Small-scale

0.561

High

993670

UBC9
SUMO-conjugating enzyme UBC9

1

8

Small-scale

0.561

High

994311

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

16

Small-scale

0.561

High

1119483

RUNX2
Runt-related transcription factor 2

1

16

Small-scale

0.561

High

1270482

MARK2
Serine/threonine-protein kinase MARK2

1

11

Small-scale

0.561

High

65115

GG6L9
Golgin subfamily A member 6-like protein 9

2

19

High-throughput

0.553

High

190241

MOT4
Monocarboxylate transporter 4

2

5

High-throughput

0.553

High

322849

MTCL2
Microtubule cross-linking factor 2

2

20

High-throughput

0.553

High

327695

UBL3
Ubiquitin-like protein 3

2

1

High-throughput

0.553

High

967223

RRAS2
Ras-related protein R-Ras2

2

10

High-throughput

0.553

High

1356776

GBG12

2

1

High-throughput

0.553

High

1356751

KAT5
Histone acetyltransferase KAT5

1

5

Small-scale

0.552

High

1132397

CASP8
Caspase-8

1

6

Small-scale

0.550

High

261429

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

20

High-throughput

0.536

High

1356764

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

20

High-throughput

0.536

High

1356766

FOXP3
Forkhead box protein P3

1

20

Small-scale

0.534

High

669198

EDNRA
Endothelin-1 receptor

1

1

Small-scale

0.523

High

85476

B7ZLY0
PHC2 protein

1

10

High-throughput

0.515

High

1232485

Q6FHY5
MEOX2 protein

1

7

High-throughput

0.515

High

1196353

ZNG1F
Zinc-regulated GTPase metalloprotein activator 1F

1

0

High-throughput

0.513

High

140378

SDCB1
Syntenin-1

1

6

Small-scale

0.501

High

508334

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

High-throughput

0.501

High

1051397

ZBT16
Zinc finger and BTB domain-containing protein 16

1

10

Small-scale

0.501

High

1131928

GNMT
Glycine N-methyltransferase

1

0

High-throughput

0.486

High

894051

MEOX2
Homeobox protein MOX-2

1

7

High-throughput

0.481

High

1312470

PHC2
Polyhomeotic-like protein 2

1

10

High-throughput

0.481

High

1341075

INADL
InaD-like protein

1

10

High-throughput

0.481

High

171288

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

8

Small-scale

0.479

High

176855

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

High-throughput

0.479

High

208710

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

216966

KLF4
Krueppel-like factor 4

1

20

Small-scale

0.479

High

242398

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

245255

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

8

High-throughput

0.479

High

252127

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

269588

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

10

High-throughput

0.479

High

281382

GGYF1
GRB10-interacting GYF protein 1

1

8

High-throughput

0.479

High

396590

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

487569

PARP1
Poly [ADP-ribose] polymerase 1

1

18

High-throughput

0.479

High

520223

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

688284

TTP
mRNA decay activator protein ZFP36

1

5

Small-scale

0.479

High

968390

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

13

Small-scale

0.479

High

1027618

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

11

High-throughput

0.479

High

1045569

TF65
Transcription factor p65

1

20

High-throughput

0.479

High

1067536

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1098359

ERCC8
DNA excision repair protein ERCC-8

1

20

Small-scale

0.479

High

1104620

IKZF1
DNA-binding protein Ikaros

1

20

Small-scale

0.479

High

1131083

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

Small-scale

0.479

High

1134016

ZN638
Zinc finger protein 638

1

6

High-throughput

0.479

High

1143071

KPCD1
Serine/threonine-protein kinase D1

1

17

Small-scale

0.479

High

1204625

BCORL
BCL-6 corepressor-like protein 1

1

11

Small-scale

0.479

High

1216077

SPD2A
SH3 and PX domain-containing protein 2A

1

7

High-throughput

0.479

High

1254803

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1309229

KSR1
Kinase suppressor of Ras 1

1

7

High-throughput

0.479

High

1313289

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

1323105

CCAR2
Cell cycle and apoptosis regulator protein 2

1

5

Small-scale

0.479

High

1352596

DEN1A
DENN domain-containing protein 1A

1

9

High-throughput

0.479

High

1356752

FBXW7
F-box/WD repeat-containing protein 7

1

15

Small-scale

0.479

High

1356757

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

10

High-throughput

0.479

High

1356758

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.479

High

1356762

RTKN
Rhotekin

1

1

High-throughput

0.479

High

1356769

IKZF4
Zinc finger protein Eos

1

20

Small-scale

0.479

High

1356771

KI13B
Kinesin-like protein KIF13B

1

11

High-throughput

0.479

High

1356772

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

5

High-throughput

0.479

High

1356778

LIMA1
LIM domain and actin-binding protein 1

1

8

High-throughput

0.479

High

1356779

IKZF3
Zinc finger protein Aiolos

1

20

Small-scale

0.479

High

1356780

ZBT21
Zinc finger and BTB domain-containing protein 21

1

6

High-throughput

0.479

High

1356781

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.479

High

1356784

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1356785

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

20

Small-scale

0.479

High

63733

A5PKX9
INADL protein

1

9

High-throughput

0.470

High

959503

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.460

High

911852

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.458

High

142378

PEX7
Peroxisomal targeting signal 2 receptor

1

20

High-throughput

0.445

High

347207

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.445

High

537592

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.445

High

840078

CASP3
Caspase-3

1

6

Small-scale

0.445

High

936923

CASP7
Caspase-7

1

6

Small-scale

0.445

High

936960

CASP9
Caspase-9

1

6

Small-scale

0.445

High

937073

CASP6
Caspase-6

1

6

Small-scale

0.445

High

1023843

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

7

High-throughput

0.445

High

1258522

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

11

High-throughput

0.445

High

1356774

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.437

High

1356775

CING
Cingulin

1

16

High-throughput

0.437

High

1356786

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

1356753

FWCH2
FLYWCH family member 2

3

0

High-throughput

0.347

High

1187433

CC036
Uncharacterized protein C3orf36

2

0

High-throughput

0.316

High

1253103

KRBA2
KRAB-A domain-containing protein 2

2

0

High-throughput

0.316

High

1356759

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

1356770

ESM1
Endothelial cell-specific molecule 1

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025