HitPredict

Interactor 1: HIRA (P79987)
Protein HIRA (cHIRA) (TUP1-like enhancer of split protein 1)
Gene: HIRA

Interactor 2: RBBP4 (Q9W7I5)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (chCAF-1 p48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Gallus gallus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	14652010, 15527972
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006355 - regulation of DNA-templated transcription GO:0031491 - nucleosome binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1019 Gg			1 425
+	Hs
		867861 HIRA_HUMAN (1-1019): 0: 780: 85.41		RBBP4_HUMAN (1-425): 6.63e-120: 357: 99.77
+	Hs
		867873 HIRA_HUMAN (1-1019): 0: 780: 85.41		RBBP7_HUMAN (2-175): 3.42e-14: 76: 11.86
+	Hs
		997700 CAF1B_HUMAN (1-522): 3.05e-81: 276: 23.23		RBBP4_HUMAN (1-425): 6.63e-120: 357: 99.77
+	Sc
		532830 CAC2_YEAST (1-420): 7.29e-87: 289: 20.08		MSI1_YEAST (3-408): 4.02e-78: 249: 28.57
+	Hs
		903171 WDR5_HUMAN (740-854): 6.74e-11: 66.8: 14.40		RBBP4_HUMAN (1-425): 6.63e-120: 357: 99.77
+	Dm
		53062 A1Z898_DROME (1-737): 3.89e-84: 290: 18.26		CAF1_DROME (272-423): 1.6e-20: 94.9: 20.12
+	Sp
		144003 YEG3_SCHPO (171-501): 2.27e-12: 72.6: 13.58		YEC6_SCHPO (14-405): 2.71e-80: 255: 31.37
+	Hs
		903418 FBXW7_HUMAN (253-466): 9.82e-20: 96.8: 12.29		WDR5_HUMAN (156-423): 1.46e-62: 206: 21.27
+	Hs
		792949 LIS1_HUMAN (687-889): 2.76e-14: 78.3: 10.38		WDR5_HUMAN (156-423): 1.46e-62: 206: 21.27
+	Hs
		903428 SNR40_HUMAN (4-157): 7.3e-13: 73.4: 19.23		WDR5_HUMAN (156-423): 1.46e-62: 206: 21.27
+	Hs
		903551 NLE1_HUMAN (717-867): 2.08e-11: 69.5: 8.64		WDR5_HUMAN (156-423): 1.46e-62: 206: 21.27
+	Hs
		282871 CIAO1_HUMAN (222-367): 1.47e-11: 69.2: 19.33		WDR5_HUMAN (156-423): 1.46e-62: 206: 21.27
+	Hs
		903077 WDR5_HUMAN (740-854): 6.74e-11: 66.8: 14.40		WDR5_HUMAN (156-423): 1.46e-62: 206: 21.27
+	Mm
		925836 LIS1_MOUSE (687-889): 2.59e-14: 78.3: 10.38		LIS1_MOUSE (2-208): 9.35e-40: 148: 10.92
+	Hs
		1083339 FBXW7_HUMAN (253-466): 9.82e-20: 96.8: 12.29		RBBP7_HUMAN (2-175): 3.42e-14: 76: 11.86
+	Hs
		1240442 POC1B_HUMAN (603-856): 3.66e-12: 71.8: 10.27		POC1A_HUMAN (2-185): 2.22e-20: 94.2: 9.47
+	Hs
		1346954 NLE1_HUMAN (717-867): 2.08e-11: 69.5: 8.64		NLE1_HUMAN (300-423): 6.56e-21: 96.4: 20.00
+	Hs
		1288270 SNR40_HUMAN (4-157): 7.3e-13: 73.4: 19.23		GRWD1_HUMAN (302-405): 2.36e-14: 76.5: 23.08
+	Ce
		954090 LIS1_CAEEL (737-889): 4.56e-13: 74.5: 11.73		LIN53_CAEEL (2-106): 1.62e-12: 70.6: 7.94