HitPredict

Interactor 1: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	25960296, 28514442, 24981860, 32068487, 33961781, 35271311, 24927542, 27705803, 11336697, 18590578, 10330177, 21888893
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 185 Hs			1 835
+	Hs
		1026971 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		800365 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Mm
		1143843 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		TIF1B_MOUSE (57-835): 5.81e-159: 486: 94.87
+	Mm
		949936 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		TIF1B_MOUSE (57-835): 5.81e-159: 486: 94.87
+	Mm
		1143019 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		TIF1B_MOUSE (57-835): 5.81e-159: 486: 94.87
+	Hs
		203676 SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1027331 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		949915 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Mm
		1145016 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		TIF1A_MOUSE (404-816): 5.62e-53: 202: 20.90
+	Hs
		170353 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Mm
		949937 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		TIF1A_MOUSE (404-816): 5.62e-53: 202: 20.90
+	Hs
		170331 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Mm
		1143020 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		TIF1A_MOUSE (404-816): 5.62e-53: 202: 20.90
+	Hs
		170295 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Mm
		1266178 Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49		TRI66_MOUSE (391-831): 1.57e-45: 179: 20.72
+	Mm
		949959 CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00		TRI66_MOUSE (391-831): 1.57e-45: 179: 20.72
+	Mm
		1143042 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		TRI66_MOUSE (391-831): 1.57e-45: 179: 20.72
+	Hs
		203631 SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Dm
		399034 HP1_DROME (1-176): 7.89e-50: 161: 42.23		Q9VDK5_DROME (408-819): 3.82e-33: 140: 13.18
+	Dm
		68987 HP1_DROME (1-176): 7.89e-50: 161: 42.23		A8WHL4_DROME (416-819): 5.56e-33: 139: 12.95