HitPredict

Interactor 1: H4 (P84040)
Histone H4
Gene: His4

Interactor 2: KMT5A (Q9VFK6)
Histone-lysine N-methyltransferase Set8 (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8)
Gene: Set8

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	19001096
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Dm			1 691
+	Hs
		917879 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		NSD3_HUMAN (346-690): 6.88e-71: 253: 18.23
+	Hs
		331767 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		NSD2_HUMAN (377-690): 1.5e-70: 252: 19.87
+	Hs
		917762 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		NSD1_HUMAN (356-690): 2.17e-68: 246: 15.73
+	Hs
		917760 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		EHMT2_HUMAN (393-690): 2.23e-66: 239: 18.67
+	Hs
		917944 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		EHMT1_HUMAN (390-690): 3.62e-66: 239: 19.81
+	Hs
		917878 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		SETD2_HUMAN (281-690): 2.27e-63: 231: 15.26
+	Hs
		917338 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		EZH2_HUMAN (324-684): 5.46e-64: 227: 15.84
+	Hs
		917987 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT5A_HUMAN (373-689): 2.83e-62: 214: 33.85
+	Sc
		356466 H4_YEAST (18-103): 5.86e-41: 132: 90.70		SET1_YEAST (392-689): 9.1e-62: 225: 21.93
+	Hs
		917145 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT2A_HUMAN (462-688): 1.82e-51: 195: 25.88
+	Hs
		165658 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		SET1A_HUMAN (456-689): 5.84e-49: 188: 25.00
+	Hs
		918135 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT2B_HUMAN (456-688): 7.46e-49: 188: 24.03