Protein: CLK4
Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)

Gene: CLK4
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q9HAZ1

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1420015

UBL5
Ubiquitin-like protein 5

2

3

Small-scale

0.800

High

284233

SRS10
Serine/arginine-rich splicing factor 10

1

20

Small-scale

0.724

High

1402591

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.710

High

74611

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

20

High-throughput

0.691

High

891798

GSK3B
Glycogen synthase kinase-3 beta

1

18

High-throughput

0.691

High

1062119

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1437868

PIM2
Serine/threonine-protein kinase pim-2

1

3

High-throughput

0.691

High

1239672

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

5

Small-scale

0.667

High

1061160

SRSF1
Serine/arginine-rich splicing factor 1

1

20

Small-scale

0.647

High

1099261

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.618

High

1099545

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.618

High

349246

LATS1
Serine/threonine-protein kinase LATS1

1

11

High-throughput

0.618

High

613187

EGR1
Early growth response protein 1

1

4

High-throughput

0.618

High

950408

KR107
Keratin-associated protein 10-7

3

8

High-throughput

0.616

High

67845

SRRM4
Serine/arginine repetitive matrix protein 4

2

1

High-throughput

0.606

High

269119

MITF
Microphthalmia-associated transcription factor

1

5

Small-scale

0.578

High

1290739

ZCH18
Zinc finger CCCH domain-containing protein 18

2

19

High-throughput

0.574

High

911384

IMA5
Importin subunit alpha-5

1

9

High-throughput

0.573

High

396979

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

950208

KR106
Keratin-associated protein 10-6

2

9

High-throughput

0.553

High

214524

RASL2
Ras GTPase-activating protein 4

1

6

High-throughput

0.553

High

1360824

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.553

High

587810

DESP
Desmoplakin

1

20

High-throughput

0.536

High

713458

SPB3
Serpin B3

1

4

High-throughput

0.536

High

1437870

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.536

High

950689

KR108
Keratin-associated protein 10-8

1

8

High-throughput

0.523

High

950896

KR109
Keratin-associated protein 10-9

1

10

High-throughput

0.523

High

1437867

RN181
E3 ubiquitin-protein ligase RNF181

1

3

High-throughput

0.494

High

230112

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

7

High-throughput

0.489

High

1384205

RGMA
Repulsive guidance molecule A

1

1

High-throughput

0.489

High

1393318

SAHH3
Adenosylhomocysteinase 3

1

7

High-throughput

0.489

High

1324456

CLASR
CLK4-associating serine/arginine rich protein

1

9

Small-scale

0.481

High

925978

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.479

High

1045785

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1118827

TF2H2
General transcription factor IIH subunit 2

1

1

High-throughput

0.479

High

1202562

Q59FZ7
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

1279904

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

12

High-throughput

0.479

High

1437869

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1314054

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

868772

LEG7
Galectin-7

1

2

High-throughput

0.445

High

950009

KR103
Keratin-associated protein 10-3

1

8

High-throughput

0.439

High

1348513

LNX1
E3 ubiquitin-protein ligase LNX

1

9

Small-scale

0.437

High

839624

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.279

Low

1358580

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025