HitPredict

Interactor 1: H2A (P84051)
Histone H2A
Gene: His2A

Interactor 2: CID (Q9V6Q2)
Histone H3-like centromeric protein cid (CENP-A homolog) (Centromere identifier protein)
Gene: CID

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	22209075, 17676993
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 124 Dm			1 225
+	Hs
		935141 H2A1A_HUMAN (1-122): 3.03e-63: 190: 89.43		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		934946 H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		555411 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		935170 H2A1J_HUMAN (1-122): 4.6e-62: 187: 89.43		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Mm
		935458 Q8CGP4_MOUSE (1-122): 9.8e-62: 186: 85.37		H31_MOUSE (91-221): 7.69e-57: 178: 31.34
+	Hs
		1086203 H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Hs
		952450 H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		1086293 H2A1J_HUMAN (1-122): 4.6e-62: 187: 89.43		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Hs
		1174590 H2A2B_HUMAN (1-122): 1.38e-62: 188: 90.24		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Hs
		555416 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		555485 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Hs
		1086278 H2A1H_HUMAN (1-122): 1.04e-61: 186: 89.43		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Hs
		1157222 H2A1J_HUMAN (1-122): 4.6e-62: 187: 89.43		H3C_HUMAN (91-221): 3.86e-55: 174: 31.58
+	Hs
		1174640 H2A1J_HUMAN (1-122): 4.6e-62: 187: 89.43		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Hs
		555517 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Mm
		952759 Q8CGP4_MOUSE (1-122): 9.8e-62: 186: 85.37		H33_MOUSE (91-221): 1.58e-55: 175: 30.60
+	Hs
		1174631 H2A1H_HUMAN (1-122): 1.04e-61: 186: 89.43		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Mm
		952264 Q8CGP4_MOUSE (1-122): 9.8e-62: 186: 85.37		H32_MOUSE (91-221): 2.49e-55: 174: 30.60
+	Hs
		555497 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		H37_HUMAN (91-221): 9.93e-54: 170: 30.60
+	Hs
		555348 H2AX_HUMAN (1-120): 6.84e-62: 187: 90.91		CENPA_HUMAN (96-220): 1.01e-45: 150: 34.35