HitPredict

Interactor 1: ARF1 (P84077)
ADP-ribosylation factor 1 (EC 3.6.5.2)
Gene: ARF1

Interactor 2: ARFG1 (Q8N6T3)
ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
Gene: ARFGAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	16332543, 19020038
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Arf~ArfGap
Common GO terms	GO:0000139 - Golgi membrane GO:0005829 - cytosol GO:0016192 - vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 406
+	Hs
		912911 ARF6_HUMAN (5-179): 2.19e-73: 219: 68.00		ACAP2_HUMAN (5-387): 3.03e-94: 301: 17.93
+	Hs
		574756 ARF4_HUMAN (1-180): 1.54e-69: 210: 80.56		ARFG3_HUMAN (1-404): 5.56e-75: 244: 21.13
+	Hs
		950718 ARF5_HUMAN (1-180): 2.95e-68: 207: 80.56		ARFG3_HUMAN (1-404): 5.56e-75: 244: 21.13
+	Hs
		897406 ARF3_HUMAN (1-181): 6.38e-68: 206: 96.13		ARFG3_HUMAN (1-404): 5.56e-75: 244: 21.13
+	Hs
		950563 ARF1_HUMAN (1-181): 5.85e-68: 206: 100.00		ARFG3_HUMAN (1-404): 5.56e-75: 244: 21.13
+	Hs
		574712 ARF4_HUMAN (1-180): 1.54e-69: 210: 80.56		ARFG2_HUMAN (3-404): 6.4e-73: 238: 18.88
+	Hs
		950654 ARF5_HUMAN (1-180): 2.95e-68: 207: 80.56		ARFG2_HUMAN (3-404): 6.4e-73: 238: 18.88
+	Hs
		897383 ARF3_HUMAN (1-181): 6.38e-68: 206: 96.13		ARFG2_HUMAN (3-404): 6.4e-73: 238: 18.88
+	Hs
		950522 ARF1_HUMAN (1-181): 5.85e-68: 206: 100.00		ARFG2_HUMAN (3-404): 6.4e-73: 238: 18.88
+	Hs
		912909 ARF6_HUMAN (5-179): 2.19e-73: 219: 68.00		ACAP1_HUMAN (9-384): 3.07e-62: 215: 12.93
+	Hs
		574718 ARF4_HUMAN (1-180): 1.54e-69: 210: 80.56		SMAP2_HUMAN (5-356): 1.14e-65: 217: 14.40
+	Ce
		1353616 Q9U2S4_CAEEL (12-178): 2.07e-86: 253: 69.46		CNT1_CAEEL (8-214): 1.36e-46: 172: 20.91
+	Hs
		897390 ARF3_HUMAN (1-181): 6.38e-68: 206: 96.13		SMAP2_HUMAN (5-356): 1.14e-65: 217: 14.40
+	At
		285978 ARF2B_ARATH (1-177): 7.31e-67: 203: 90.40		AGD7_ARATH (4-386): 2.81e-65: 217: 24.94
+	Sc
		503072 ARF1_YEAST (1-179): 4.31e-65: 199: 77.65		GCS1_YEAST (3-332): 3.17e-62: 205: 25.47
+	Hs
		913181 ARF6_HUMAN (5-179): 2.19e-73: 219: 68.00		ASAP1_HUMAN (6-89): 2.45e-12: 70.9: 38.10
+	Sc
		580854 ARF2_YEAST (1-180): 1.01e-65: 201: 77.22		GLO3_YEAST (6-87): 6.22e-17: 84.3: 46.34
+	Sc
		503086 ARF1_YEAST (1-179): 4.31e-65: 199: 77.65		GLO3_YEAST (6-87): 6.22e-17: 84.3: 46.34
+	Mm
		1186345 RAB1B_MOUSE (5-180): 7.02e-66: 202: 18.23		ASAP2_MOUSE (6-88): 2.42e-14: 77: 45.78
+	Hs
		950577 ARF1_HUMAN (1-181): 5.85e-68: 206: 100.00		ASAP1_HUMAN (6-89): 2.45e-12: 70.9: 38.10