HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0070878 - primary miRNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 746
+	Hs
		1079987 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		992789 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1028670 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		266999 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		853908 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1031345 PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		516536 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1028558 SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		963528 TIAR_HUMAN (1-95): 5.6e-18: 81.1: 26.00		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		952203 SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		331802 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		516645 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		331871 RBM4B_HUMAN (11-88): 5.29e-18: 81.1: 28.21		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		331795 SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		331803 SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1029077 SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Sc
		376833 PABP_YEAST (2-93): 6.85e-19: 84.2: 20.62		SET2_YEAST (470-733): 1.22e-59: 216: 25.56
+	Hs
		975239 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		975231 SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		975240 SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54