Protein: PTPA
Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')

Gene: PTPA
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q15257

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994230

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

12

Small-scale

0.847

High

951979

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

3

10

High-throughput

0.839

High

977499

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

12

High-throughput

0.691

High

1144566

AMOT
Angiomotin

3

2

High-throughput

0.667

High

717819

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

3

Small-scale

0.653

High

186549

TRI18
E3 ubiquitin-protein ligase Midline-1

3

1

Small-scale

0.647

High

1144591

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

3

0

High-throughput

0.634

High

1144570

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

2

1

High-throughput

0.628

High

529836

TAU
Microtubule-associated protein tau

3

0

Small-scale

0.623

High

967747

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.618

High

728249

AKT1
RAC-alpha serine/threonine-protein kinase

2

1

Small-scale

0.602

High

219734

FOXO3
Forkhead box protein O3

2

1

Small-scale

0.595

High

1144575

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.580

High

1144587

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.580

High

1102168

ATM
Serine-protein kinase ATM

2

0

Small-scale

0.559

High

1144588

RGAP1
Rac GTPase-activating protein 1

1

0

Small-scale

0.554

High

1054179

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

Small-scale

0.537

High

1144567

SGO1
Shugoshin 1

1

0

Small-scale

0.537

High

1144589

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.537

High

610673

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.536

High

821363

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.536

High

875973

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.536

High

881937

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.536

High

899050

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.536

High

899396

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.536

High

1007028

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.536

High

1144583

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.536

High

909277

CCNG1
Cyclin-G1

1

0

Small-scale

0.529

High

1144571

GASP3
G protein-coupled receptor associated sorting protein 3

1

0

Small-scale

0.529

High

1144578

NMD3A
Glutamate receptor ionotropic, NMDA 3A

1

0

Small-scale

0.529

High

436673

KPCB
Protein kinase C beta type

1

1

Small-scale

0.501

High

940969

HDAC4
Histone deacetylase 4

1

2

Small-scale

0.501

High

1144582

AURKB
Aurora kinase B

1

1

Small-scale

0.501

High

249290

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.493

High

1144568

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.493

High

162942

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.480

High

422135

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

591658

H2AX
Histone H2AX

1

0

Small-scale

0.480

High

666994

CCNE1
G1/S-specific cyclin-E1

1

0

Small-scale

0.480

High

891567

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.480

High

1109552

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.480

High

1144579

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

Small-scale

0.480

High

1144584

TEP1
Telomerase protein component 1

1

0

Small-scale

0.480

High

1144585

ST4A1
Sulfotransferase 4A1

1

0

Small-scale

0.480

High

241741

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

464965

SP1
Transcription factor Sp1

1

1

Small-scale

0.479

High

699755

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.479

High

827793

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

828211

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.479

High

838102

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.479

High

858658

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

Small-scale

0.479

High

1005323

IGBP1
Immunoglobulin-binding protein 1

1

2

Small-scale

0.479

High

1036880

SP3
Transcription factor Sp3

1

1

Small-scale

0.479

High

1144572

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1144593

STK26
Serine/threonine-protein kinase 26

1

1

High-throughput

0.479

High

1144594

HDAC6
Protein deacetylase HDAC6

1

2

Small-scale

0.479

High

1144595

INT6
Integrator complex subunit 6

1

1

Small-scale

0.479

High

59917

A2BDD9
AMOT protein

1

2

High-throughput

0.470

High

259982

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

326957

UBE4B
Ubiquitin conjugation factor E4 B

1

0

Small-scale

0.458

High

363314

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.458

High

396154

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

447046

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

522100

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.458

High

713094

NOS3
Nitric oxide synthase 3

1

0

Small-scale

0.458

High

732602

ARRB2
Beta-arrestin-2

1

0

Small-scale

0.458

High

764767

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

772815

MYH9
Myosin-9

1

0

High-throughput

0.458

High

858584

IEX1
Radiation-inducible immediate-early gene IEX-1

1

0

Small-scale

0.458

High

889570

CLK2
Dual specificity protein kinase CLK2

1

0

Small-scale

0.458

High

904293

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

951683

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1024365

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.458

High

1028208

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1029297

SET
Protein SET

1

0

Small-scale

0.458

High

1041074

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

1128725

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1130048

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.458

High

1144563

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

Small-scale

0.458

High

1144564

MK14
Mitogen-activated protein kinase 14

1

0

Small-scale

0.458

High

1144565

F110C
Protein FAM110C

1

0

Small-scale

0.458

High

1144569

GFI1B
Zinc finger protein Gfi-1b

1

0

Small-scale

0.458

High

1144573

TBA1A
Tubulin alpha-1A chain

1

0

Small-scale

0.458

High

1144574

MARK2
Serine/threonine-protein kinase MARK2

1

0

Small-scale

0.458

High

1144576

MYCD
Myocardin

1

0

High-throughput

0.458

High

1144577

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1144581

MYL11
Myosin regulatory light chain 11

1

0

High-throughput

0.458

High

907438

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

Small-scale

0.445

High

1144586

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.438

High

598736

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1007697

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.426

High

1144590

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

516094

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

1144592

SPG21
Maspardin

2

0

High-throughput

0.316

High

567776

TF
Tissue factor

1

0

Small-scale

0.261

Low

1144580

KISSR
KiSS-1 receptor

1

0

Small-scale

0.261

Low

105971

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

353344

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

423966

CP17A
Steroid 17-alpha-hydroxylase/17,20 lyase

1

0

Small-scale

0.249

Low

1103966

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025