Protein: PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC 3.1.3.16)

Gene: PP2A1, PPH21
Organism: Saccharomyces cerevisiae S288C
Interactions: 84
UniProt ID: P23594

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000159 - protein phosphatase type 2A complex
GO:0000278 - mitotic cell cycle
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660816

TAP42
Type 2A phosphatase-associated protein 42

10

20

Small-scale

0.978

High

660776

2AAA
Protein phosphatase PP2A regulatory subunit A

10

20

Small-scale

0.977

High

660789

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

8

20

Small-scale

0.971

High

660823

TIP41
Type 2A phosphatase activator TIP41

3

6

Small-scale

0.864

High

660825

PTPA2
Serine/threonine-protein phosphatase 2A activator 2

3

12

Small-scale

0.840

High

660769

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

2

14

High-throughput

0.789

High

660812

2ABA
Protein phosphatase PP2A regulatory subunit B

19

20

Small-scale

0.765

High

660809

FAR11
Factor arrest protein 11

2

5

Small-scale

0.757

High

660806

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

3

2

High-throughput

0.675

High

660784

CDC27
Anaphase-promoting complex subunit CDC27

1

5

Small-scale

0.647

High

660811

ACT
Actin

1

8

High-throughput

0.646

High

660778

TOR2
Serine/threonine-protein kinase TOR2

2

11

Small-scale

0.621

High

660780

SWE1
Mitosis inhibitor protein kinase SWE1

2

20

Small-scale

0.619

High

660799

PTPA1
Serine/threonine-protein phosphatase 2A activator 1

1

12

Small-scale

0.618

High

660810

ZDS2
Protein ZDS2

2

3

Small-scale

0.606

High

660803

ZDS1
Protein ZDS1

2

5

Small-scale

0.601

High

626595

HSP60
Heat shock protein 60, mitochondrial

2

15

High-throughput

0.584

High

660820

SGO1
Shugoshin

2

1

Small-scale

0.584

High

578884

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.575

High

660768

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

13

Small-scale

0.575

High

660787

PPME1
Protein phosphatase methylesterase 1

2

4

Small-scale

0.565

High

660814

GIS1
Transcriptional activator/repressor GIS1

1

7

Small-scale

0.561

High

660808

IGO1
mRNA stability protein IGO1

2

0

Small-scale

0.559

High

660796

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

660788

BZZ1
Protein BZZ1

1

1

High-throughput

0.541

High

459027

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.536

High

470023

GAL7
Galactose-1-phosphate uridylyltransferase

1

1

High-throughput

0.536

High

470102

SPS1
Sporulation-specific protein 1

1

20

High-throughput

0.536

High

656366

KC11
Casein kinase I homolog 1

1

15

High-throughput

0.536

High

660826

RUVB2
RuvB-like protein 2

1

10

High-throughput

0.536

High

553946

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.521

High

421264

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

3

High-throughput

0.515

High

660804

HFM1
ATP-dependent DNA helicase MER3

1

4

High-throughput

0.515

High

660805

BTN2
Protein BTN2

1

0

High-throughput

0.513

High

479249

CDC6
Cell division control protein 6

1

1

Small-scale

0.501

High

486756

CDC16
Anaphase-promoting complex subunit CDC16

1

8

Small-scale

0.501

High

509407

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

15

High-throughput

0.501

High

660770

MPIP
M-phase inducer phosphatase

1

1

Small-scale

0.501

High

660807

APC1
Anaphase-promoting complex subunit 1

1

2

Small-scale

0.501

High

660821

APC9
Anaphase-promoting complex subunit 9

1

1

Small-scale

0.501

High

660822

SCC1
Sister chromatid cohesion protein 1

1

3

Small-scale

0.501

High

405033

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.500

High

598957

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

5

High-throughput

0.500

High

660771

SCJ1
DnaJ-related protein SCJ1

1

5

High-throughput

0.500

High

660773

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.500

High

660801

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.500

High

660824

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.493

High

598308

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.489

High

660783

CENPA
Histone H3-like centromeric protein CSE4

1

4

Small-scale

0.481

High

660785

SIC1
Protein SIC1

1

0

Small-scale

0.480

High

660797

SECU
Securin

1

0

Small-scale

0.480

High

441718

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

454889

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

502862

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.479

High

632405

CG12
G1/S-specific cyclin CLN2

1

9

Small-scale

0.479

High

660775

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

660781

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

660782

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

660786

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

660790

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

660800

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.479

High

660802

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

660813

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

660815

RUVB1
RuvB-like protein 1

1

10

High-throughput

0.479

High

660818

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

660819

CORO
Coronin-like protein

1

6

High-throughput

0.470

High

660779

CDC13
Cell division control protein 13

1

1

Small-scale

0.457

High

594203

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.457

High

510217

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

523110

HSP71
Heat shock protein SSA1

1

16

High-throughput

0.445

High

543873

SSB1
Ribosome-associated molecular chaperone SSB1

1

18

High-throughput

0.445

High

660777

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

660794

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.445

High

660817

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

541145

SYLM
Leucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.437

High

660774

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.437

High

660791

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.437

High

660792

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.437

High

660793

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.437

High

660798

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.437

High

660795

FIR1
Factor interacting with REF2

1

0

High-throughput

0.269

Low

571028

CHS2
Chitin synthase 2

1

0

Small-scale

0.261

Low

660772

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025