HitPredict

Interactor 1: 1433E (P92177)
14-3-3 protein epsilon (Suppressor of Ras1 3-9)
Gene: 14-3-3epsilon

Interactor 2: IRS1 (Q9XTN2)
Insulin receptor substrate 1 (dIRS) (Protein chico)
Gene: chico

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	22068330, 26839216, 27626673, 17956857
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008340 - determination of adult lifespan and 1 others more... GO:0045927 - positive regulation of growth
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 262 Dm			1 968
+	Dm
		664678 1433Z_DROME (2-247): 5.14e-135: 382: 65.85		IRS1_DROME (1-968): 0: 1755: 100.00
+	Hs
		724526 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		IRS1_HUMAN (1-355): 4.78e-140: 451: 29.13
+	Mm
		724581 1433E_MOUSE (1-261): 2.02e-147: 413: 82.38		IRS1_MOUSE (1-355): 6.15e-138: 446: 30.71
+	Hs
		910201 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		IRS2_HUMAN (9-357): 3.78e-116: 389: 26.17
+	Hs
		151760 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		IRS4_HUMAN (7-369): 6.55e-98: 337: 23.53