HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PDE3A (Q14432)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Gene: PDE3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1141
+	Hs
		1015438 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		962043 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		581046 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		1015410 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		955124 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		962012 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		581021 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		466236 RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		252974 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PDE8A_HUMAN (607-1050): 1.63e-130: 420: 23.34
+	Hs
		252961 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PDE8A_HUMAN (607-1050): 1.63e-130: 420: 23.34
+	Hs
		252957 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		PDE8A_HUMAN (607-1050): 1.63e-130: 420: 23.34
+	Hs
		902309 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		PDE6C_HUMAN (594-1065): 3.84e-117: 385: 20.70