Protein: PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)

Gene: PDE8A
Organism: Homo sapiens
Interactions: 26
UniProt ID: O60658

Gene Ontology (top 5):
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005829 - cytosol
GO:0006198 - cAMP catabolic process
GO:0006355 - regulation of DNA-templated transcription
GO:0019900 - kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252967

U119A
Protein unc-119 homolog A

4

1

High-throughput

0.691

High

252952

PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

1

7

High-throughput

0.665

High

252971

TRIB1
Tribbles homolog 1

1

10

High-throughput

0.536

High

252966

NR1H3
Oxysterols receptor LXR-alpha

1

0

High-throughput

0.513

High

252953

RASK
GTPase KRas

1

2

High-throughput

0.479

High

252954

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

252955

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

252956

ENPL
Endoplasmin

1

1

High-throughput

0.479

High

252957

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

252958

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

Small-scale

0.479

High

252959

IKBA
NF-kappa-B inhibitor alpha

1

3

Small-scale

0.479

High

252960

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

252961

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

252962

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

6

Small-scale

0.479

High

252963

RELB
Transcription factor RelB

1

4

Small-scale

0.479

High

252964

TF65
Transcription factor p65

1

4

Small-scale

0.479

High

252965

REL
Proto-oncogene c-Rel

1

4

Small-scale

0.479

High

252968

IKBB
NF-kappa-B inhibitor beta

1

3

Small-scale

0.479

High

252970

NPHP3
Nephrocystin-3

1

1

High-throughput

0.479

High

252974

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.479

High

252975

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.479

High

252976

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

252951

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

252973

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

252969

OCLN
Occludin

1

0

High-throughput

0.249

Low

252972

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025