Protein: PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)

Gene: PDE3B
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q13370

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1103534

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

8

High-throughput

0.691

High

821712

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.679

High

1103567

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

3

1

High-throughput

0.667

High

1103609

TX264
Testis-expressed protein 264

3

0

High-throughput

0.638

High

1043857

KCNC4
Voltage-gated potassium channel KCNC4

2

3

High-throughput

0.628

High

1103556

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

3

High-throughput

0.628

High

1103578

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

3

High-throughput

0.628

High

191962

TEX28
Testis-specific protein TEX28

2

0

High-throughput

0.602

High

944914

TMPS3
Transmembrane protease serine 3

2

0

High-throughput

0.602

High

1103579

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

4

High-throughput

0.601

High

335731

RPGF3
Rap guanine nucleotide exchange factor 3

1

2

Small-scale

0.597

High

255540

HPGDS
Hematopoietic prostaglandin D synthase

2

0

High-throughput

0.580

High

1103561

I17RC
Interleukin-17 receptor C

2

1

High-throughput

0.574

High

1103607

PCDC2
Protocadherin alpha-C2

2

1

High-throughput

0.574

High

1103549

S39A4
Zinc transporter ZIP4

2

1

High-throughput

0.571

High

1103543

PI3R6
Phosphoinositide 3-kinase regulatory subunit 6

1

0

Small-scale

0.561

High

951135

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

1103539

EREP1
Endosomal transmembrane epsin interactor 1

2

1

High-throughput

0.558

High

1103566

LNX1
E3 ubiquitin-protein ligase LNX

2

2

High-throughput

0.553

High

1004048

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.553

High

380540

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

2

1

High-throughput

0.552

High

270149

LRP3
Low-density lipoprotein receptor-related protein 3

1

1

High-throughput

0.536

High

547319

CP19A
Aromatase

1

1

High-throughput

0.536

High

595044

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.536

High

728214

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

High-throughput

0.536

High

1009144

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

1

High-throughput

0.536

High

1010461

EREP3
Protein ENTREP3

1

1

High-throughput

0.536

High

1085314

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

5

High-throughput

0.536

High

1103570

ZDH12
Palmitoyltransferase ZDHHC12

1

2

High-throughput

0.536

High

1103602

AKT3
RAC-gamma serine/threonine-protein kinase

1

8

High-throughput

0.536

High

484128

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.513

High

1103535

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1103540

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.513

High

1103541

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1103586

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1103593

TLR9
Toll-like receptor 9

1

0

High-throughput

0.513

High

1103601

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

0

High-throughput

0.513

High

1103581

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.489

High

1103606

PCDGL
Protocadherin gamma-C4

1

1

High-throughput

0.489

High

877419

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

0

Small-scale

0.479

High

466236

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.479

High

581021

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

680345

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

894722

EMD
Emerin

1

1

High-throughput

0.479

High

901793

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

944364

NAC3
Sodium/calcium exchanger 3

1

1

High-throughput

0.479

High

947182

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.479

High

955124

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.479

High

962012

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

966274

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971482

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.479

High

990185

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1015410

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1026993

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

1049257

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1058401

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

1103533

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

7

High-throughput

0.479

High

1103544

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1103554

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

1103562

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1103568

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1103572

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

1103577

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

1103597

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1103599

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.479

High

1103600

ALK
ALK tyrosine kinase receptor

1

2

High-throughput

0.479

High

48236

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.458

High

173911

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

291317

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

417412

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418103

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

611106

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

837598

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

847517

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880536

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

903898

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

946551

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.458

High

989837

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

0

High-throughput

0.458

High

1103532

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1103538

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1103557

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1103558

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1103563

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1103574

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1103580

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1103583

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1103588

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1103589

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1103592

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1103594

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1103608

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.458

High

933514

S12A3
Solute carrier family 12 member 3

1

2

High-throughput

0.445

High

1103536

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.445

High

1103537

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.445

High

1103542

S27A3
Long-chain fatty acid transport protein 3

1

3

High-throughput

0.445

High

1103548

S27A4
Long-chain fatty acid transport protein 4

1

3

High-throughput

0.445

High

1103551

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

4

High-throughput

0.445

High

1103564

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

1103565

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

1103576

SL9A7
Sodium/hydrogen exchanger 7

1

3

High-throughput

0.445

High

1103605

S27A5
Long-chain fatty acid transport protein 5

1

3

High-throughput

0.445

High

212902

LRRT2
Leucine-rich repeat transmembrane neuronal protein 2

1

4

High-throughput

0.437

High

887417

CEBPD
CCAAT/enhancer-binding protein delta

1

1

Small-scale

0.437

High

1103545

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

1103552

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1103584

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.437

High

1103585

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1103587

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

190220

MOT4
Monocarboxylate transporter 4

1

0

High-throughput

0.426

High

1103547

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1103553

S49A3
Solute carrier family 49 member A3

1

0

High-throughput

0.426

High

1103559

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

690976

1433T
14-3-3 protein theta

1

20

Small-scale

0.408

High

877662

SL9A3
Sodium/hydrogen exchanger 3

1

3

High-throughput

0.407

High

1103546

SL9A4
Sodium/hydrogen exchanger 4

1

3

High-throughput

0.407

High

1103604

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.407

High

1103590

ANRA2
Ankyrin repeat family A protein 2

1

0

Small-scale

0.391

High

1103550

LRC8B
Volume-regulated anion channel subunit LRRC8B

2

0

High-throughput

0.328

High

1103571

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.328

High

1103596

MARH4
E3 ubiquitin-protein ligase MARCHF4

2

0

High-throughput

0.318

High

1103598

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

2

0

High-throughput

0.318

High

1088765

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

0

High-throughput

0.279

Low

1103531

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

High-throughput

0.279

Low

1103555

CLC14
C-type lectin domain family 14 member A

1

0

High-throughput

0.279

Low

1103569

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1103591

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

548330

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.249

Low

1029427

IL9R
Interleukin-9 receptor

1

0

High-throughput

0.249

Low

1103560

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1103582

TMM59
Transmembrane protein 59

1

0

High-throughput

0.249

Low

1103595

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1103603

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.249

Low

1103573

B3A4
Anion exchange protein 4

1

0

High-throughput

0.232

Low

1103575

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025