HitPredict - High confidence protein-protein interactions

Interactor 1: PSN1 (P97887)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: Psen1

Interactor 2: NICA (Q8CGU6)
Nicastrin
Gene: Ncstn

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12297508
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005769 - early endosome GO:0005783 - endoplasmic reticulum GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 24 others more... GO:0006509 - membrane protein ectodomain proteolysis GO:0007219 - Notch signaling pathway GO:0007220 - Notch receptor processing GO:0007611 - learning or memory GO:0008021 - synaptic vesicle GO:0008233 - peptidase activity GO:0016020 - membrane GO:0016485 - protein processing GO:0021549 - cerebellum development GO:0032991 - protein-containing complex GO:0034205 - amyloid-beta formation GO:0042383 - sarcolemma GO:0042500 - aspartic endopeptidase activity, intramembrane cleaving GO:0042734 - presynaptic membrane GO:0042982 - amyloid precursor protein metabolic process GO:0042987 - amyloid precursor protein catabolic process GO:0043085 - positive regulation of catalytic activity GO:0050435 - amyloid-beta metabolic process GO:0050673 - epithelial cell proliferation GO:0051117 - ATPase binding GO:0051402 - neuron apoptotic process GO:0070765 - gamma-secretase complex GO:0070851 - growth factor receptor binding GO:0097060 - synaptic membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	468
Rn

1	708

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Last updated: 15 Jul 2024