HitPredict

Interactor 1: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Interactor 2: FBW10 (Q5XX13)
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)
Gene: FBXW10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	37277019
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 1052
+	Hs
		984340 UB2D4_HUMAN (1-147): 8.97e-84: 243: 91.84		GBB2_HUMAN (469-774): 1.69e-52: 189: 11.99
+	Hs
		906640 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		GBB2_HUMAN (469-774): 1.69e-52: 189: 11.99
+	Hs
		982161 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		GBB2_HUMAN (469-774): 1.69e-52: 189: 11.99
+	Hs
		957056 UB2D3_HUMAN (1-147): 6.9e-82: 239: 100.00		GBB2_HUMAN (469-774): 1.69e-52: 189: 11.99
+	Hs
		906772 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		TBL1R_HUMAN (525-830): 2e-49: 185: 12.00
+	Hs
		261387 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		TBL1X_HUMAN (514-840): 3.56e-48: 183: 11.27
+	Hs
		1381199 UB2E3_HUMAN (4-146): 1.4e-74: 222: 65.73		TBL1R_HUMAN (525-830): 2e-49: 185: 12.00
+	Hs
		261432 UB2E3_HUMAN (4-146): 1.4e-74: 222: 65.73		TBL1X_HUMAN (514-840): 3.56e-48: 183: 11.27
+	Hs
		957805 UBE2N_HUMAN (4-147): 5.95e-69: 206: 46.53		FBXW7_HUMAN (559-835): 2.82e-42: 167: 13.82
+	Dm
		232057 UBCD1_DROME (1-147): 1.16e-82: 241: 93.88		O44382_DROME (131-452): 8.65e-23: 105: 10.91
+	Hs
		906830 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		FBW1A_HUMAN (602-761): 5.89e-17: 87.6: 10.63
+	Hs
		982372 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		FBW1A_HUMAN (602-761): 5.89e-17: 87.6: 10.63
+	Hs
		957246 UB2D3_HUMAN (1-147): 6.9e-82: 239: 100.00		FBW1A_HUMAN (602-761): 5.89e-17: 87.6: 10.63
+	At
		201035 UBC28_ARATH (1-147): 1.13e-83: 243: 79.59		GBLPA_ARATH (451-601): 6.62e-16: 82: 33.54
+	At
		200936 UBC9_ARATH (1-147): 1.18e-82: 241: 79.59		GBLPA_ARATH (451-601): 6.62e-16: 82: 33.54
+	At
		200937 UBC10_ARATH (1-147): 1.3e-82: 241: 78.91		GBLPA_ARATH (451-601): 6.62e-16: 82: 33.54
+	At
		200938 UBC11_ARATH (1-147): 8.41e-83: 241: 78.91		GBLPA_ARATH (451-601): 6.62e-16: 82: 33.54
+	Hs
		957234 UB2D3_HUMAN (1-147): 6.9e-82: 239: 100.00		FBW1B_HUMAN (602-686): 5.1e-13: 74.8: 16.47