HitPredict

Interactor 1: TSG6 (P98066)
Tumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)
Gene: TNFAIP6

Interactor 2: CCL19 (Q99731)
C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19)
Gene: CCL19

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	27044744
Identification Methods	surface plasmon resonance, solid phase assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006954 - inflammatory response
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 277 Hs			1 98
+	Hs
		945627 TSG6_HUMAN (12-277): 2.95e-95: 283: 100.00		CCL7_HUMAN (21-94): 4.48e-27: 96.7: 27.03
+	Hs
		528215 TSG6_HUMAN (12-277): 2.95e-95: 283: 100.00		CCL2_HUMAN (24-94): 7.47e-25: 91.3: 25.35
+	Hs
		528258 TSG6_HUMAN (12-277): 2.95e-95: 283: 100.00		CCL5_HUMAN (11-89): 1.78e-23: 87.4: 30.38
+	Hs
		134297 TSG6_HUMAN (12-277): 2.95e-95: 283: 100.00		CCL21_HUMAN (19-95): 6.89e-23: 87: 34.18
+	Hs
		234417 NRP2_HUMAN (132-276): 2.27e-34: 133: 28.38		CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78
+	Hs
		561754 PCOC2_HUMAN (135-271): 2.6e-32: 124: 29.93		CL3L1_HUMAN (1-90): 3.74e-30: 104: 30.00
+	Hs
		486349 PCOC2_HUMAN (135-271): 2.6e-32: 124: 29.93		CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78
+	Hs
		486217 BMP1_HUMAN (131-273): 9.48e-28: 114: 27.97		CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78
+	Hs
		486218 CSPG2_HUMAN (33-137): 6.58e-17: 82.5: 29.73		CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78
+	Hs
		486313 HPLN3_HUMAN (33-129): 6.44e-17: 81.3: 37.76		CCL3_HUMAN (1-90): 6.55e-29: 101: 27.78
+	Hs
		530375 CSPG2_HUMAN (33-137): 6.58e-17: 82.5: 29.73		CCL8_HUMAN (13-95): 3.44e-27: 97: 24.71
+	Hs
		528198 CSPG2_HUMAN (33-137): 6.58e-17: 82.5: 29.73		CCL2_HUMAN (24-94): 7.47e-25: 91.3: 25.35
+	Hs
		528230 CSPG2_HUMAN (33-137): 6.58e-17: 82.5: 29.73		CCL5_HUMAN (11-89): 1.78e-23: 87.4: 30.38
+	Hs
		134289 CSPG2_HUMAN (33-137): 6.58e-17: 82.5: 29.73		CCL21_HUMAN (19-95): 6.89e-23: 87: 34.18
+	Hs
		530374 CSPG2_HUMAN (33-137): 6.58e-17: 82.5: 29.73		CCL20_HUMAN (3-93): 2.11e-22: 84.7: 29.67