HitPredict

Interactor 1: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: SHIP2 (Q6P549)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
Gene: Inppl1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	20697350, 14502564
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Mm			1 1257
+	Hs
		176390 SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17		SHIP2_HUMAN (1-1257): 0: 909: 95.79
+	Mm
		957245 SHC1_MOUSE (1-579): 0: 536: 100.00		SHIP1_MOUSE (19-1181): 0: 739: 39.87
+	Hs
		666147 SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17		SHIP1_HUMAN (21-1201): 0: 708: 39.03
+	Rn
		956852 SHC1_RAT (111-579): 3.86e-152: 447: 98.08		SHIP1_RAT (19-1181): 0: 741: 40.07
+	Mm
		1159871 SH2B2_MOUSE (339-577): 1.01e-36: 146: 21.14		SHIP2_MOUSE (1-1257): 0: 951: 100.00
+	Hs
		145960 SH2B2_HUMAN (339-577): 5.95e-43: 164: 21.14		SHIP2_HUMAN (1-1257): 0: 909: 95.79
+	Hs
		176388 P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75		SHIP2_HUMAN (1-1257): 0: 909: 95.79
+	Hs
		129144 P85B_HUMAN (479-576): 2.03e-18: 91.2: 23.53		SHIP2_HUMAN (1-1257): 0: 909: 95.79
+	Mm
		403460 SRC_MOUSE (334-570): 3.59e-44: 166: 16.87		SHIP1_MOUSE (19-1181): 0: 739: 39.87
+	Hs
		557759 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SHIP1_HUMAN (21-1201): 0: 708: 39.03
+	Mm
		643112 P85A_MOUSE (479-575): 6.35e-19: 92.7: 24.75		SHIP1_MOUSE (19-1181): 0: 739: 39.87
+	Hs
		655433 P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75		SHIP1_HUMAN (21-1201): 0: 708: 39.03
+	Hs
		166030 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SYNJ2_HUMAN (273-1231): 3.62e-170: 546: 16.62
+	Hs
		166024 FYN_HUMAN (367-579): 2.26e-40: 156: 18.86		SYNJ2_HUMAN (273-1231): 3.62e-170: 546: 16.62
+	Hs
		522919 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		OCRL_HUMAN (314-924): 5.52e-151: 479: 21.40
+	Hs
		166032 P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75		SYNJ2_HUMAN (273-1231): 3.62e-170: 546: 16.62
+	Hs
		412137 FYN_HUMAN (367-579): 2.26e-40: 156: 18.86		OCRL_HUMAN (314-924): 5.52e-151: 479: 21.40
+	Ce
		105280 Q95PW9_CAEEL (386-577): 2.49e-35: 139: 20.10		SYNJ_CAEEL (273-1024): 2.03e-147: 476: 19.16
+	Mm
		292397 FYN_MOUSE (367-579): 2.26e-40: 156: 18.86		SH21A_MOUSE (22-134): 7.45e-21: 91.3: 42.61
+	Hs
		203208 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SYNJ1_HUMAN (722-1154): 1.51e-10: 68.1: 8.81