HitPredict

Interactor 1: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: JIP2 (Q13387)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: MAPK8IP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.50	0.556

Property	Details
Experiments	10827173, 12508107
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4655 Hs			1 824
+	Mm
		57562 LRP2_MOUSE (22-4655): 0: 3723: 76.66		JIP2_MOUSE (1-824): 3.34e-153: 470: 84.87
+	Hs
		957621 LRP2_HUMAN (1-4655): 0: 3803: 100.00		ANS1B_HUMAN (536-809): 1.38e-53: 204: 15.88
+	Hs
		957612 LRP2_HUMAN (1-4655): 0: 3803: 100.00		ARH_HUMAN (660-809): 3.74e-40: 152: 18.42
+	Hs
		957662 LRP2_HUMAN (1-4655): 0: 3803: 100.00		JIP1_HUMAN (13-351): 1.71e-16: 86: 18.75
+	Rn
		88518 LRP2_RAT (1-4655): 0: 3738: 76.27		ARH_RAT (660-809): 7.83e-36: 139: 19.08
+	Mm
		57558 LRP2_MOUSE (22-4655): 0: 3723: 76.66		ARH_MOUSE (660-809): 4.1e-38: 146: 19.08
+	Mm
		57563 LRP2_MOUSE (22-4655): 0: 3723: 76.66		JIP1_MOUSE (13-351): 1.03e-18: 93.3: 19.09
+	Hs
		1032902 LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92		JIP2_HUMAN (1-824): 9.09e-151: 464: 100.00
+	Mm
		1266181 LRP8_MOUSE (2623-2869): 2.33e-11: 72.6: 16.36		JIP2_MOUSE (1-824): 3.34e-153: 470: 84.87
+	Mm
		69886 B1AXJ3_MOUSE (3424-3628): 4.43e-11: 71.8: 12.50		JIP2_MOUSE (1-824): 3.34e-153: 470: 84.87
+	Mm
		1265299 LRP1_MOUSE (3672-3974): 3.08e-09: 66: 10.16		JIP2_MOUSE (1-824): 3.34e-153: 470: 84.87
+	Hs
		992661 LRP1_HUMAN (1102-1387): 4.45e-09: 65.6: 13.59		JIP2_HUMAN (1-824): 9.09e-151: 464: 100.00
+	Hs
		992682 LRP1_HUMAN (1102-1387): 4.45e-09: 65.6: 13.59		ANS1B_HUMAN (536-809): 1.38e-53: 204: 15.88
+	Hs
		351073 LDLR_HUMAN (927-1187): 1.96e-15: 86: 17.65		ARH_HUMAN (660-809): 3.74e-40: 152: 18.42
+	Hs
		992719 LRP1_HUMAN (1102-1387): 4.45e-09: 65.6: 13.59		GULP1_HUMAN (663-814): 1.23e-42: 159: 24.84
+	Mm
		1257662 LRP4_MOUSE (180-440): 7.8e-20: 101: 21.12		JIP1_MOUSE (13-351): 1.03e-18: 93.3: 19.09
+	Hs
		1048463 LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92		JIP1_HUMAN (13-351): 1.71e-16: 86: 18.75
+	Mm
		1266182 LRP8_MOUSE (2623-2869): 2.33e-11: 72.6: 16.36		JIP1_MOUSE (13-351): 1.03e-18: 93.3: 19.09
+	Mm
		69888 B1AXJ3_MOUSE (3424-3628): 4.43e-11: 71.8: 12.50		JIP1_MOUSE (13-351): 1.03e-18: 93.3: 19.09
+	Mm
		1265300 LRP1_MOUSE (3672-3974): 3.08e-09: 66: 10.16		JIP1_MOUSE (13-351): 1.03e-18: 93.3: 19.09