HitPredict

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: BIRC8 (Q96P09)
Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis)
Gene: BIRC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~BIR, BIR~zf-C3HC4_3, zf-C3HC4_3~zf-C3HC4_3
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0031398 - positive regulation of protein ubiquitination
GO:0043027 - cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 - negative regulation of apoptotic process
and 4 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 497
Hs

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Last updated: 15 Jul 2024