Protein: ROS1
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)

Gene: ROS1
Organism: Homo sapiens
Interactions: 92
UniProt ID: P08922

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0002066 - columnar/cuboidal epithelial cell development
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

477212

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.832

High

477261

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.691

High

477207

FGFR4
Fibroblast growth factor receptor 4

1

19

High-throughput

0.647

High

477221

COPA
Coatomer subunit alpha

1

12

High-throughput

0.646

High

477246

PDZD8
PDZ domain-containing protein 8

1

5

High-throughput

0.646

High

477262

OSBL8
Oxysterol-binding protein-related protein 8

1

12

High-throughput

0.646

High

467983

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

477269

VAV3
Guanine nucleotide exchange factor VAV3

1

20

Small-scale

0.618

High

477214

COPB2
Coatomer subunit beta'

1

11

High-throughput

0.578

High

477236

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.578

High

477230

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.555

High

477208

TBG1
Tubulin gamma-1 chain

1

20

High-throughput

0.553

High

477217

SERPH
Serpin H1

1

6

High-throughput

0.553

High

477250

ARHG2
Rho guanine nucleotide exchange factor 2

1

20

High-throughput

0.553

High

332833

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

18

High-throughput

0.536

High

477234

STIM1
Stromal interaction molecule 1

1

16

High-throughput

0.536

High

477264

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.536

High

477267

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.536

High

477272

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.536

High

107792

SUMO5
Small ubiquitin-related modifier 5

1

1

High-throughput

0.514

High

477205

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.514

High

477274

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.512

High

63292

ODAD3
Outer dynein arm-docking complex subunit 3

1

17

High-throughput

0.500

High

158760

AP3D1
AP-3 complex subunit delta-1

1

14

High-throughput

0.500

High

211720

ZW10
Centromere/kinetochore protein zw10 homolog

1

1

High-throughput

0.500

High

280990

TACC1
Transforming acidic coiled-coil-containing protein 1

1

19

High-throughput

0.500

High

343881

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.500

High

477200

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

18

High-throughput

0.500

High

477201

BIP
Endoplasmic reticulum chaperone BiP

1

19

High-throughput

0.500

High

477210

CALX
Calnexin

1

17

High-throughput

0.500

High

477213

PEBP1
Phosphatidylethanolamine-binding protein 1

1

4

High-throughput

0.500

High

477215

COPD
Coatomer subunit delta

1

7

High-throughput

0.500

High

477218

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.500

High

477220

COPB
Coatomer subunit beta

1

10

High-throughput

0.500

High

477231

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.500

High

477233

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.500

High

477235

MESD
LRP chaperone MESD

1

1

High-throughput

0.500

High

477237

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

5

High-throughput

0.500

High

477243

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.500

High

477251

ASTRA
Protein Aster-A

1

7

High-throughput

0.500

High

477252

DAZP1
DAZ-associated protein 1

1

13

High-throughput

0.500

High

477254

CK5P3
CDK5 regulatory subunit-associated protein 3

1

6

High-throughput

0.500

High

477257

CLCC1
Chloride channel CLIC-like protein 1

1

8

High-throughput

0.500

High

477259

NTPCR
Cancer-related nucleoside-triphosphatase

1

10

High-throughput

0.500

High

477260

ESYT1
Extended synaptotagmin-1

1

13

High-throughput

0.500

High

477266

VAPA
Vesicle-associated membrane protein-associated protein A

1

18

High-throughput

0.500

High

477203

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.489

High

477219

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

10

High-throughput

0.489

High

477239

GLPK5
Glycerol kinase 5

1

0

High-throughput

0.479

High

221509

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

4

High-throughput

0.479

High

255561

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

6

High-throughput

0.479

High

333920

SMC2
Structural maintenance of chromosomes protein 2

1

12

High-throughput

0.479

High

426181

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

7

High-throughput

0.479

High

468972

SRPRA
Signal recognition particle receptor subunit alpha

1

10

High-throughput

0.479

High

477202

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.479

High

477204

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

13

High-throughput

0.479

High

477216

EMD
Emerin

1

12

High-throughput

0.479

High

477222

EPIPL
Epiplakin

1

18

High-throughput

0.479

High

477223

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

10

High-throughput

0.479

High

477224

ABCE1
ATP-binding cassette sub-family E member 1

1

7

High-throughput

0.479

High

477225

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

7

High-throughput

0.479

High

477227

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

High-throughput

0.479

High

477229

VIGLN
Vigilin

1

8

High-throughput

0.479

High

477244

NUP93
Nuclear pore complex protein Nup93

1

3

High-throughput

0.479

High

477248

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.479

High

477249

NU205
Nuclear pore complex protein Nup205

1

6

High-throughput

0.479

High

477265

DD19A
ATP-dependent RNA helicase DDX19A

1

5

High-throughput

0.479

High

477268

BAZ1B
Tyrosine-protein kinase BAZ1B

1

11

High-throughput

0.479

High

477270

SMC3
Structural maintenance of chromosomes protein 3

1

13

High-throughput

0.479

High

158096

COPE
Coatomer subunit epsilon

1

6

High-throughput

0.457

High

477199

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

5

High-throughput

0.457

High

477209

HMGB2
High mobility group protein B2

1

12

High-throughput

0.457

High

477211

PSB6
Proteasome subunit beta type-6

1

3

High-throughput

0.457

High

477226

COPZ1
Coatomer subunit zeta-1

1

6

High-throughput

0.457

High

477240

TPGS1
Tubulin polyglutamylase complex subunit 1

1

1

High-throughput

0.457

High

477241

LRC49
Leucine-rich repeat-containing protein 49

1

20

High-throughput

0.457

High

477247

SCFD1
Sec1 family domain-containing protein 1

1

16

High-throughput

0.457

High

477253

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.457

High

477258

SDF2
Stromal cell-derived factor 2

1

9

High-throughput

0.457

High

477263

TMX1
Thioredoxin-related transmembrane protein 1

1

20

High-throughput

0.457

High

477273

SNX5
Sorting nexin-5

1

20

High-throughput

0.457

High

137623

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

6

High-throughput

0.437

High

277524

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.437

High

477206

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

6

High-throughput

0.437

High

477232

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

9

High-throughput

0.437

High

477242

PHF6
PHD finger protein 6

1

11

High-throughput

0.437

High

477255

RBM14
RNA-binding protein 14

1

16

High-throughput

0.437

High

477271

TRRAP
Transformation/transcription domain-associated protein

1

11

High-throughput

0.437

High

477228

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.269

Low

477238

SANBR
SANT and BTB domain regulator of class switch recombination

1

0

High-throughput

0.261

Low

477245

TBC19
TBC1 domain family member 19

1

0

High-throughput

0.261

Low

477256

HS3S6
Heparan sulfate glucosamine 3-O-sulfotransferase 6

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025