Protein: EIF3D
Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)

Gene: EIF3D
Organism: Homo sapiens
Interactions: 228
UniProt ID: O15371

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002191 - cap-dependent translational initiation
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176775

EIF3I
Eukaryotic translation initiation factor 3 subunit I

7

2

Small-scale

0.963

High

176844

EIF3C
Eukaryotic translation initiation factor 3 subunit C

6

2

Small-scale

0.939

High

176670

EIF3H
Eukaryotic translation initiation factor 3 subunit H

11

1

Small-scale

0.755

High

176780

EIF3A
Eukaryotic translation initiation factor 3 subunit A

11

1

Small-scale

0.755

High

176800

A16L1
Autophagy-related protein 16-1

2

2

High-throughput

0.754

High

176748

EIF3E
Eukaryotic translation initiation factor 3 subunit E

9

2

Small-scale

0.753

High

124673

EIF3F
Eukaryotic translation initiation factor 3 subunit F

9

1

Small-scale

0.750

High

176883

EIF3L
Eukaryotic translation initiation factor 3 subunit L

7

1

Small-scale

0.747

High

176746

EIF3B
Eukaryotic translation initiation factor 3 subunit B

6

1

Small-scale

0.735

High

176679

EIF3G
Eukaryotic translation initiation factor 3 subunit G

8

0

Small-scale

0.718

High

176809

EIF3M
Eukaryotic translation initiation factor 3 subunit M

7

0

Small-scale

0.713

High

78258

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

2

High-throughput

0.691

High

176688

HERC2
E3 ubiquitin-protein ligase HERC2

4

1

Small-scale

0.683

High

176764

CSK21
Casein kinase II subunit alpha

3

2

High-throughput

0.667

High

176873

EIF3K
Eukaryotic translation initiation factor 3 subunit K

4

0

Small-scale

0.660

High

176876

ZRAN1
Ubiquitin thioesterase ZRANB1

3

1

High-throughput

0.653

High

176711

TRI27
Zinc finger protein RFP

3

0

High-throughput

0.646

High

176869

HOME3
Homer protein homolog 3

3

0

High-throughput

0.646

High

176673

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.640

High

176749

IF4A1
Eukaryotic initiation factor 4A-I

2

2

High-throughput

0.628

High

176836

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.618

High

176878

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.618

High

176880

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.618

High

176718

CSK22
Casein kinase II subunit alpha'

2

2

High-throughput

0.611

High

176785

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

2

High-throughput

0.611

High

176782

IF4A2
Eukaryotic initiation factor 4A-II

2

2

High-throughput

0.601

High

176734

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.586

High

176761

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.586

High

176847

ANM1
Protein arginine N-methyltransferase 1

2

0

High-throughput

0.585

High

176768

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

2

1

Small-scale

0.584

High

166852

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

0

High-throughput

0.580

High

176677

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

176823

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.580

High

176835

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.580

High

176837

HOOK2
Protein Hook homolog 2

2

0

High-throughput

0.580

High

176868

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

176698

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

176699

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.571

High

176680

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

Small-scale

0.559

High

176689

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

176779

CUL3
Cullin-3

2

0

Small-scale

0.559

High

176805

MORN3
MORN repeat-containing protein 3

2

1

High-throughput

0.553

High

176681

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.553

High

176753

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.553

High

176721

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.549

High

176769

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

176848

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.549

High

176820

NGEF
Ephexin-1

2

0

High-throughput

0.547

High

176838

DOCK6
Dedicator of cytokinesis protein 6

2

0

High-throughput

0.547

High

176831

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.541

High

176728

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

176733

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.536

High

176774

MTA1
Metastasis-associated protein MTA1

1

1

High-throughput

0.536

High

176796

PRC2B
Protein PRRC2B

1

4

High-throughput

0.536

High

176808

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

Small-scale

0.536

High

176827

PHLA1
Pleckstrin homology-like domain family A member 1

1

0

Small-scale

0.529

High

176826

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.517

High

128363

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

133772

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.513

High

176678

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

176682

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

176692

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

176700

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

176704

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

176713

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

High-throughput

0.513

High

176735

MATR3
Matrin-3

1

0

High-throughput

0.513

High

176736

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

176737

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

176739

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

176741

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

176744

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

176745

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

176755

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

176757

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

176816

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

176818

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

176821

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

176829

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

176840

SCYL1
N-terminal kinase-like protein

1

0

High-throughput

0.513

High

176846

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

176877

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

174452

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

176687

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

121894

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.493

High

176675

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.493

High

176723

COF1
Cofilin-1

1

0

High-throughput

0.493

High

176849

MTA3
Metastasis-associated protein MTA3

1

1

High-throughput

0.489

High

176874

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.486

High

176834

CBP
CREB-binding protein

1

1

Small-scale

0.481

High

176750

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

162212

XPO1
Exportin-1

1

2

High-throughput

0.479

High

176671

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

1

High-throughput

0.479

High

176683

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

176707

BIP
Endoplasmic reticulum chaperone BiP

1

1

Small-scale

0.479

High

176720

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

176725

DDX6
Probable ATP-dependent RNA helicase DDX6

1

2

High-throughput

0.479

High

176727

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

176738

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

176751

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

176756

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

176762

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.479

High

176766

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

176770

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

176772

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

176773

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

176777

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

2

High-throughput

0.479

High

176781

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

176784

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

176787

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

176788

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.479

High

176815

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

176822

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

176862

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

176884

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

176861

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.464

High

125010

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

176672

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

176685

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

176694

RASK
GTPase KRas

1

0

High-throughput

0.458

High

176696

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

176702

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

176708

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

176709

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.458

High

176717

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

176719

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

176722

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

176724

IF4B
Eukaryotic translation initiation factor 4B

1

0

Small-scale

0.458

High

176731

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

176732

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

176742

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

176752

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

176754

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

176759

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

176760

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

176763

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

176765

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

176771

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

176776

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

176783

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

176786

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

176789

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

176790

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

176793

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

176798

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

176799

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

176801

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

176803

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

176804

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

176810

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

176812

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

176813

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

176814

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

176825

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

176828

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

176832

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

176843

NECD
Necdin

1

0

High-throughput

0.458

High

176854

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

176855

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

176856

GAN
Gigaxonin

1

0

High-throughput

0.458

High

176858

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

176864

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

176865

ANLN
Anillin

1

0

High-throughput

0.458

High

176866

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

176881

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

176767

ERCC6
DNA excision repair protein ERCC-6

1

3

High-throughput

0.457

High

176852

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

176703

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

176706

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

176747

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

176802

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.445

High

176853

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.445

High

176684

ST17B
Serine/threonine-protein kinase 17B

1

2

High-throughput

0.437

High

176697

FINC
Fibronectin

1

1

High-throughput

0.437

High

176778

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

2

High-throughput

0.437

High

176806

BCOR
BCL-6 corepressor

1

2

High-throughput

0.437

High

176807

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

176833

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

176842

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.437

High

176859

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

176875

ST17A
Serine/threonine-protein kinase 17A

1

2

High-throughput

0.437

High

176882

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.437

High

120754

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

176691

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

176710

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

176794

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

176797

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

62243

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

176730

TRI23
E3 ubiquitin-protein ligase TRIM23

2

0

High-throughput

0.316

High

176758

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.316

High

176791

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

176795

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

0

High-throughput

0.316

High

176817

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.316

High

176850

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.316

High

176871

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

176693

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.305

High

176811

BEND5
BEN domain-containing protein 5

1

0

High-throughput

0.299

High

176716

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.298

High

176690

MBD3
Methyl-CpG-binding domain protein 3

1

0

High-throughput

0.279

Low

176705

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

176792

TUSC1
Tumor suppressor candidate gene 1 protein

1

0

High-throughput

0.279

Low

176830

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.279

Low

176857

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.279

Low

176863

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.279

Low

176872

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.279

Low

176885

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.269

Low

118117

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.249

Low

176674

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

176676

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

176686

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

176695

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

176701

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

176712

ETS1
Protein C-ets-1

1

0

High-throughput

0.249

Low

176714

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

176715

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

176726

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

176729

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

176740

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

176743

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

176819

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

176824

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

176839

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

176841

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

176851

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

176860

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.249

Low

176867

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

176870

PD1L1
Programmed cell death 1 ligand 1

1

0

Small-scale

0.249

Low

176845

GFI1
Zinc finger protein Gfi-1

1

0

Small-scale

0.238

Low

176879

PPM1H
Protein phosphatase 1H

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024