Protein: LMTK2
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)

Gene: LMTK2
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q8IWU2

Gene Ontology (top 5):
GO:0001881 - receptor recycling
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004864 - protein phosphatase inhibitor activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1310851

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

Small-scale

0.710

High

1310883

MYO6
Unconventional myosin-VI

4

12

Small-scale

0.703

High

711149

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

High-throughput

0.698

High

1144533

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

786711

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

11

9

Small-scale

0.693

High

1025484

CDK5
Cyclin-dependent kinase 5

1

20

Small-scale

0.680

High

337115

NPT2B
Sodium-dependent phosphate transport protein 2B

3

1

High-throughput

0.662

High

834129

IPP2
Protein phosphatase inhibitor 2

2

1

Small-scale

0.644

High

1050810

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.625

High

440140

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

463635

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

630875

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.618

High

631670

RAB6A
Ras-related protein Rab-6A

1

20

High-throughput

0.618

High

705712

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

20

High-throughput

0.618

High

966584

1433G
14-3-3 protein gamma

1

20

High-throughput

0.618

High

976396

RB11A
Ras-related protein Rab-11A

1

14

High-throughput

0.618

High

967841

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

9

Small-scale

0.596

High

1110492

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

10

High-throughput

0.575

High

730752

1433S
14-3-3 protein sigma

1

20

High-throughput

0.553

High

901923

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.553

High

1049530

1433F
14-3-3 protein eta

1

20

High-throughput

0.553

High

593855

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

13

High-throughput

0.541

High

776983

PPM1A
Protein phosphatase 1A

1

15

High-throughput

0.541

High

884833

PPM1F
Protein phosphatase 1F

1

20

High-throughput

0.541

High

1310886

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

20

High-throughput

0.541

High

64953

ARRD5
Arrestin domain-containing protein 5

1

7

High-throughput

0.536

High

1310867

SORT
Sortilin

1

9

High-throughput

0.536

High

270663

ATP9A
Probable phospholipid-transporting ATPase IIA

1

4

High-throughput

0.515

High

1214722

ATD3B
ATPase family AAA domain-containing protein 3B

1

20

High-throughput

0.500

High

1310887

INVS
Inversin

1

17

High-throughput

0.500

High

58736

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

20

High-throughput

0.494

High

326734

DUS14
Dual specificity protein phosphatase 14

1

20

High-throughput

0.494

High

719349

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.494

High

968369

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

9

High-throughput

0.494

High

1163848

DUS6
Dual specificity protein phosphatase 6

1

20

High-throughput

0.494

High

1229392

DUS29
Dual specificity phosphatase 29

1

20

High-throughput

0.494

High

1251089

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

20

High-throughput

0.494

High

1310854

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

20

High-throughput

0.494

High

1310859

DUS19
Dual specificity protein phosphatase 19

1

20

High-throughput

0.494

High

1310860

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.494

High

1310874

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

20

High-throughput

0.494

High

1310884

CC14A
Dual specificity protein phosphatase CDC14A

1

20

High-throughput

0.494

High

189685

STX7
Syntaxin-7

1

9

High-throughput

0.479

High

226115

STX6
Syntaxin-6

1

6

High-throughput

0.479

High

244172

KIF5C
Kinesin heavy chain isoform 5C

1

15

High-throughput

0.479

High

299275

FLOT1
Flotillin-1

1

17

High-throughput

0.479

High

327346

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.479

High

426299

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

9

High-throughput

0.479

High

487504

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.479

High

604080

CXA1
Gap junction alpha-1 protein

1

17

High-throughput

0.479

High

749960

KINH
Kinesin-1 heavy chain

1

15

High-throughput

0.479

High

894884

EMD
Emerin

1

10

High-throughput

0.479

High

906430

DHB4
Peroxisomal multifunctional enzyme type 2

1

4

High-throughput

0.479

High

957786

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

7

High-throughput

0.479

High

959205

ABCE1
ATP-binding cassette sub-family E member 1

1

13

High-throughput

0.479

High

1008226

PRKDC
DNA-dependent protein kinase catalytic subunit

1

17

High-throughput

0.479

High

1041161

CAV1
Caveolin-1

1

14

High-throughput

0.479

High

1060543

KLC1
Kinesin light chain 1

1

13

High-throughput

0.479

High

1062540

DHX9
ATP-dependent RNA helicase A

1

13

High-throughput

0.479

High

1139642

SYK
Lysine--tRNA ligase

1

8

High-throughput

0.479

High

1163655

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

1

High-throughput

0.479

High

1168838

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

13

High-throughput

0.479

High

1310045

DEN6A
Protein DENND6A

1

3

High-throughput

0.479

High

1310852

NUP93
Nuclear pore complex protein Nup93

1

6

High-throughput

0.479

High

1310863

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

13

High-throughput

0.479

High

1310870

RFIP5
Rab11 family-interacting protein 5

1

20

High-throughput

0.479

High

1310873

KLC2
Kinesin light chain 2

1

15

High-throughput

0.479

High

1310880

DD19A
ATP-dependent RNA helicase DDX19A

1

11

High-throughput

0.479

High

278888

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

1310856

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

0

High-throughput

0.458

High

1310878

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

839585

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.457

High

1287306

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.457

High

211149

CTR4
Cationic amino acid transporter 4

1

19

High-throughput

0.445

High

538634

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

4

High-throughput

0.445

High

845072

EAA3
Excitatory amino acid transporter 3

1

15

High-throughput

0.445

High

880848

NRAM2
Natural resistance-associated macrophage protein 2

1

1

High-throughput

0.445

High

1239512

ZNT6
Zinc transporter 6

1

6

High-throughput

0.445

High

1251153

ZNT10
Calcium/manganese antiporter SLC30A10

1

6

High-throughput

0.445

High

1310869

SC6A7
Sodium-dependent proline transporter

1

15

High-throughput

0.445

High

1310871

S46A2
Solute carrier family 46 member 2

1

10

High-throughput

0.445

High

1310885

FLVC2
Choline/ethanolamine transporter FLVCR2

1

6

High-throughput

0.445

High

277736

H2AY
Core histone macro-H2A.1

1

8

High-throughput

0.437

High

627677

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

7

High-throughput

0.437

High

973064

RS29
Small ribosomal subunit protein uS14

1

3

High-throughput

0.437

High

977035

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

3

High-throughput

0.437

High

1040162

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

18

High-throughput

0.437

High

1065287

SSRP1
FACT complex subunit SSRP1

1

14

High-throughput

0.437

High

1066144

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

8

High-throughput

0.437

High

1148859

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

20

High-throughput

0.437

High

1159741

OCLN
Occludin

1

10

High-throughput

0.437

High

1227016

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.437

High

1233328

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.437

High

1310861

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.437

High

1310862

ESR2
Estrogen receptor beta

1

14

High-throughput

0.437

High

1310864

P5CR2
Pyrroline-5-carboxylate reductase 2

1

4

High-throughput

0.437

High

1310865

YTDC1
YTH domain-containing protein 1

1

7

High-throughput

0.437

High

1310866

RBM14
RNA-binding protein 14

1

17

High-throughput

0.437

High

1310868

EBP2
Probable rRNA-processing protein EBP2

1

2

High-throughput

0.437

High

1310877

XPO5
Exportin-5

1

18

High-throughput

0.437

High

1310879

KLC4
Kinesin light chain 4

1

16

High-throughput

0.437

High

1310882

STML2
Stomatin-like protein 2, mitochondrial

1

8

High-throughput

0.437

High

1310888

SP16H
FACT complex subunit SPT16

1

6

High-throughput

0.437

High

828577

S26A3
Chloride anion exchanger

1

0

High-throughput

0.426

High

1310855

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.426

High

628423

KLK2
Kallikrein-2

1

11

High-throughput

0.407

High

880172

PTH2R
Parathyroid hormone 2 receptor

1

13

High-throughput

0.407

High

912691

CTR2
Cationic amino acid transporter 2

1

20

High-throughput

0.407

High

1168610

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.407

High

1310853

LAT4
Large neutral amino acids transporter small subunit 4

1

1

High-throughput

0.407

High

1310858

MOT10
Monocarboxylate transporter 10

1

11

High-throughput

0.407

High

1310872

S13A1
Solute carrier family 13 member 1

1

3

High-throughput

0.407

High

1310881

RHCG
Ammonium transporter Rh type C

1

3

High-throughput

0.407

High

1310875

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.261

Low

1310857

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.249

Low

1310876

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025