HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: UBP10 (Q14694)
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Gene: USP10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20096447
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 491 Hs			1 798
+	Hs
		271073 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		962979 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP42_HUMAN (300-795): 2.8e-89: 309: 21.71
+	Hs
		259276 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP12_HUMAN (377-796): 1.48e-89: 288: 18.43
+	Hs
		169220 MDM4_HUMAN (4-489): 0: 531: 32.08		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		169314 MDM4_HUMAN (4-489): 0: 531: 32.08		UBP22_HUMAN (374-795): 4.81e-87: 287: 19.17