HitPredict

Interactor 1: TIAR (Q01085)
Nucleolysin TIAR (TIA-1-related protein)
Gene: TIAL1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.39	1.00	0.625

Property	Details
Experiments	29109149
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0010494 - cytoplasmic stress granule
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 414
+	Hs
		1025728 PABP4_HUMAN (2-288): 4.71e-64: 217: 24.15		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		162035 PABP4_HUMAN (2-288): 4.71e-64: 217: 24.15		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		680439 TIAR_HUMAN (1-375): 3.87e-98: 298: 100.00		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Hs
		516471 TIAR_HUMAN (1-375): 3.87e-98: 298: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		474021 PABP4_HUMAN (2-288): 4.71e-64: 217: 24.15		PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96
+	Hs
		963520 TIAR_HUMAN (1-375): 3.87e-98: 298: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		516495 PABP4_HUMAN (2-288): 4.71e-64: 217: 24.15		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Mm
		857368 TIA1_MOUSE (1-99): 2.57e-12: 69.4: 25.25		TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14
+	Dm
		1248852 Q9VAX3_DROME (11-191): 7.29e-13: 71.6: 26.50		Q8SXP8_DROME (3-389): 1.44e-71: 235: 44.58
+	Hs
		161948 PABP1_HUMAN (195-285): 4.67e-12: 69.4: 25.77		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		516424 PABP1_HUMAN (195-285): 4.67e-12: 69.4: 25.77		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Sc
		376562 PABP_YEAST (1-197): 5.72e-39: 148: 23.59		PABP_YEAST (86-269): 2.74e-34: 136: 21.88
+	Dm
		1361605 Q9VAX3_DROME (11-191): 7.29e-13: 71.6: 26.50		Q9W1I0_DROME (4-323): 2.53e-60: 200: 50.00
+	Hs
		680422 TIA1_HUMAN (3-216): 8.68e-32: 125: 22.22		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Sc
		376694 PUB1_YEAST (9-176): 2.96e-33: 130: 42.60		PABP_YEAST (86-269): 2.74e-34: 136: 21.88
+	Sc
		376993 PABP_YEAST (1-197): 5.72e-39: 148: 23.59		HRP1_YEAST (101-289): 6.38e-20: 93.6: 31.50
+	Hs
		680450 TIA1_HUMAN (3-216): 8.68e-32: 125: 22.22		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Mm
		665745 PABP1_MOUSE (195-285): 5.01e-12: 69.4: 25.77		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		516339 PABP1_HUMAN (195-285): 4.67e-12: 69.4: 25.77		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95