Protein: HLAG
HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]

Gene: HLAG, HLA-G
Organism: Homo sapiens
Interactions: 132
UniProt ID: P17693

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002451 - peripheral B cell tolerance induction
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607386

LIRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

7

20

Small-scale

0.962

High

607346

HLAG
HLA class I histocompatibility antigen, alpha chain G

6

16

Small-scale

0.941

High

607394

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

4

20

Small-scale

0.906

High

607358

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

4

19

Small-scale

0.867

High

520739

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

16

High-throughput

0.861

High

409255

HLAA
HLA class I histocompatibility antigen, A alpha chain

3

15

High-throughput

0.847

High

378901

CD8A
T-cell surface glycoprotein CD8 alpha chain

3

3

Small-scale

0.840

High

568033

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

16

High-throughput

0.811

High

607348

HLAF
HLA class I histocompatibility antigen, alpha chain F

2

16

High-throughput

0.811

High

607412

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

2

20

Small-scale

0.768

High

379863

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

15

High-throughput

0.712

High

320861

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

3

High-throughput

0.691

High

380256

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

19

High-throughput

0.691

High

380611

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

19

High-throughput

0.691

High

409557

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.691

High

607349

TGFR1
TGF-beta receptor type-1

1

2

High-throughput

0.691

High

607360

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

607361

IDD
Integral membrane protein DGCR2/IDD

1

5

High-throughput

0.691

High

607384

ANR46
Ankyrin repeat domain-containing protein 46

1

4

High-throughput

0.691

High

607393

CADM4
Cell adhesion molecule 4

1

3

High-throughput

0.691

High

607398

NEUFC
Neuferricin

1

2

High-throughput

0.691

High

607402

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

4

High-throughput

0.691

High

607403

HMR1
Major histocompatibility complex class I-related protein 1

1

16

High-throughput

0.691

High

607410

HPLN3
Hyaluronan and proteoglycan link protein 3

1

1

High-throughput

0.691

High

607425

MRC2
C-type mannose receptor 2

1

11

High-throughput

0.691

High

607433

JAG2
Protein jagged-2

1

1

High-throughput

0.691

High

607440

ST14
Suppressor of tumorigenicity 14 protein

1

12

High-throughput

0.691

High

607366

MSLN
Mesothelin

1

0

High-throughput

0.656

High

607352

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

607353

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

20

Small-scale

0.618

High

607371

IL27B
Interleukin-27 subunit beta

1

4

Small-scale

0.618

High

607375

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

4

High-throughput

0.618

High

380217

HLAH
Putative HLA class I histocompatibility antigen, alpha chain H

1

15

High-throughput

0.575

High

380520

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

20

High-throughput

0.575

High

471718

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

4

Small-scale

0.575

High

607347

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

Small-scale

0.575

High

607415

PXL2A
Peroxiredoxin-like 2A

2

1

High-throughput

0.574

High

395449

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

61086

T131L
Transmembrane protein 131-like

1

3

High-throughput

0.536

High

160994

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

12

High-throughput

0.536

High

175319

PLXB2
Plexin-B2

1

8

High-throughput

0.536

High

274858

LRP5
Low-density lipoprotein receptor-related protein 5

1

1

High-throughput

0.536

High

276996

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

2

High-throughput

0.536

High

287522

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

High-throughput

0.536

High

350684

NOE2
Noelin-2

1

1

High-throughput

0.536

High

354083

CLPT1
Putative lipid scramblase CLPTM1

1

1

High-throughput

0.536

High

551946

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

571224

PERF
Perforin-1

1

1

High-throughput

0.536

High

607350

SCNNA
Epithelial sodium channel subunit alpha

1

8

High-throughput

0.536

High

607351

ECE1
Endothelin-converting enzyme 1

1

4

High-throughput

0.536

High

607354

MA2A2
Alpha-mannosidase 2x

1

1

High-throughput

0.536

High

607355

PLXA3
Plexin-A3

1

7

High-throughput

0.536

High

607359

ASIC1
Acid-sensing ion channel 1

1

8

High-throughput

0.536

High

607362

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

18

High-throughput

0.536

High

607368

S39A6
Zinc transporter ZIP6

1

13

High-throughput

0.536

High

607369

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.536

High

607372

MBTP1
Membrane-bound transcription factor site-1 protease

1

3

High-throughput

0.536

High

607373

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.536

High

607378

AGRF1
Adhesion G-protein coupled receptor F1

1

3

High-throughput

0.536

High

607380

SE1L3
Protein sel-1 homolog 3

1

1

High-throughput

0.536

High

607381

CNNM4
Metal transporter CNNM4

1

3

High-throughput

0.536

High

607382

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

1

High-throughput

0.536

High

607383

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

3

High-throughput

0.536

High

607385

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

1

High-throughput

0.536

High

607389

UXS1
UDP-glucuronic acid decarboxylase 1

1

2

High-throughput

0.536

High

607390

CHSTE
Carbohydrate sulfotransferase 14

1

3

High-throughput

0.536

High

607391

DIK2A
Divergent protein kinase domain 2A

1

1

High-throughput

0.536

High

607392

NLGN2
Neuroligin-2

1

1

High-throughput

0.536

High

607396

GPX8
Probable glutathione peroxidase 8

1

1

High-throughput

0.536

High

607400

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

2

High-throughput

0.536

High

607401

TM131
Transmembrane protein 131

1

4

High-throughput

0.536

High

607406

ARSG
Arylsulfatase G

1

1

High-throughput

0.536

High

607411

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

3

High-throughput

0.536

High

607414

CSTN3
Calsyntenin-3

1

6

High-throughput

0.536

High

607418

SEM6B
Semaphorin-6B

1

2

High-throughput

0.536

High

607420

CHSTC
Carbohydrate sulfotransferase 12

1

3

High-throughput

0.536

High

607421

SEM4G
Semaphorin-4G

1

4

High-throughput

0.536

High

607423

CC50A
Cell cycle control protein 50A

1

5

High-throughput

0.536

High

607428

PLXA1
Plexin-A1

1

6

High-throughput

0.536

High

607430

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

12

High-throughput

0.536

High

607432

GBRT
Gamma-aminobutyric acid receptor subunit theta

1

6

High-throughput

0.536

High

607434

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

4

High-throughput

0.536

High

607437

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.536

High

607439

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

2

High-throughput

0.536

High

607441

AGRG1
Adhesion G-protein coupled receptor G1

1

3

High-throughput

0.536

High

607379

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.517

High

211909

SPIT1
Kunitz-type protease inhibitor 1

1

0

High-throughput

0.513

High

244441

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.513

High

247501

FZD6
Frizzled-6

1

0

High-throughput

0.513

High

607365

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

607374

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.513

High

607397

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

0

High-throughput

0.513

High

607399

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.513

High

607404

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

607408

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.513

High

607417

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.513

High

607419

MER34
Endogenous retroviral envelope protein HEMO

1

0

High-throughput

0.513

High

607426

SUSD2
Sushi domain-containing protein 2

1

0

High-throughput

0.513

High

607429

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.513

High

607357

CDC42
Cell division control protein 42 homolog

1

18

High-throughput

0.501

High

320942

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.489

High

607376

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

5

High-throughput

0.489

High

607377

MKS3
Meckelin

1

1

High-throughput

0.489

High

607388

TTC13
Tetratricopeptide repeat protein 13

1

2

High-throughput

0.489

High

607405

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

607407

BSCL2
Seipin

1

1

High-throughput

0.489

High

607409

LMF1
Lipase maturation factor 1

1

1

High-throughput

0.489

High

607427

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

607435

DJC16
DnaJ homolog subfamily C member 16

1

9

High-throughput

0.489

High

607438

TBL2
Transducin beta-like protein 2

1

1

High-throughput

0.489

High

461124

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

468045

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

533870

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

573317

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

607356

COPB
Coatomer subunit beta

1

1

Small-scale

0.479

High

607363

TAP1
Antigen peptide transporter 1

1

9

Small-scale

0.479

High

607364

TAP2
Antigen peptide transporter 2

1

9

Small-scale

0.479

High

607416

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.479

High

607436

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.458

High

533987

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

1

High-throughput

0.437

High

591469

H2AX
Histone H2AX

1

1

Small-scale

0.437

High

607413

TEP1
Telomerase protein component 1

1

2

High-throughput

0.437

High

607431

COR1C
Coronin-1C

1

3

High-throughput

0.437

High

190303

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.426

High

76094

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.279

Low

607370

LAMB3
Laminin subunit beta-3

1

0

High-throughput

0.279

Low

607387

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

607395

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.279

Low

607422

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.279

Low

607424

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.279

Low

607367

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025