HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Hs			1 471
+	Hs
		1069757 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		NONO_HUMAN (1-471): 1.15e-97: 303: 100.00
+	Mm
		1142788 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		NONO_MOUSE (1-471): 4.7e-94: 294: 98.31
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Mm
		1207136 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		PSPC1_MOUSE (20-470): 5.48e-67: 225: 57.40
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Mm
		1142777 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		PSPC1_MOUSE (20-470): 5.48e-67: 225: 57.40
+	Hs
		613537 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		642763 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV4_HUMAN (40-205): 3.53e-60: 203: 28.02
+	Hs
		318686 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Hs
		613422 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		1077435 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		967171 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV3_HUMAN (54-270): 2.36e-48: 171: 22.46
+	Hs
		318573 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		967202 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (30-384): 3.77e-37: 145: 16.50
+	Mm
		1207135 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		RBM4_MOUSE (75-182): 5.42e-09: 59.7: 35.71
+	Hs
		318667 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RAVR1_HUMAN (76-221): 8.34e-12: 69.4: 24.70
+	Hs
		318712 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RBM4B_HUMAN (75-182): 7.1e-09: 59.3: 35.71
+	Hs
		318716 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71