HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: PHAR4 (Q8IZ21)
Phosphatase and actin regulator 4
Gene: PHACTR4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008157 - protein phosphatase 1 binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 702
+	Hs
		786719 PP1G_HUMAN (1-330): 0: 579: 90.66		PHAR4_HUMAN (1-702): 2.05e-74: 256: 100.00
+	Mm
		73048 PP1A_MOUSE (1-330): 0: 614: 99.70		B1AVP0_MOUSE (5-702): 7.75e-46: 175: 33.90
+	Hs
		968261 PP1B_HUMAN (1-330): 0: 568: 87.88		DYST_HUMAN (354-699): 3.25e-41: 165: 15.13
+	Hs
		94463 PP1A_HUMAN (1-330): 0: 614: 100.00		D6REX3_HUMAN (83-523): 8.45e-26: 115: 12.64
+	Dm
		559092 PP12_DROME (7-304): 0: 553: 93.29		Q9VZM9_DROME (16-702): 2.79e-35: 145: 25.27
+	Hs
		967917 PP1A_HUMAN (1-330): 0: 614: 100.00		PHAR3_HUMAN (3-263): 3.87e-15: 80.8: 24.52
+	Hs
		967955 PP1A_HUMAN (1-330): 0: 614: 100.00		PHAR1_HUMAN (8-237): 4.18e-15: 80.8: 29.13
+	Hs
		967727 PP1A_HUMAN (1-330): 0: 614: 100.00		MDC1_HUMAN (3-529): 3.76e-12: 72.3: 10.55
+	Hs
		786786 PP1G_HUMAN (1-330): 0: 579: 90.66		PHAR3_HUMAN (3-263): 3.87e-15: 80.8: 24.52
+	Hs
		968410 PP1B_HUMAN (1-330): 0: 568: 87.88		PHAR3_HUMAN (3-263): 3.87e-15: 80.8: 24.52
+	Dm
		119664 PP1B_DROME (6-326): 0: 551: 83.49		M9PB30_DROME (177-611): 1.38e-12: 73.8: 12.28
+	Hs
		994221 PP2AA_HUMAN (8-302): 3.15e-176: 492: 47.30		MDC1_HUMAN (3-529): 3.76e-12: 72.3: 10.55