Protein: PHAR4
Phosphatase and actin regulator 4

Gene: PHAR4, PHACTR4
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q8IZ21

Gene Ontology (top 5):
GO:0001755 - neural crest cell migration
GO:0001843 - neural tube closure
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0007266 - Rho protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

952952

ACTB
Actin, cytoplasmic 1

3

20

High-throughput

0.847

High

993242

ACTG
Actin, cytoplasmic 2

2

20

High-throughput

0.789

High

786719

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

5

12

Small-scale

0.713

High

691230

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

730041

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.678

High

967846

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

12

High-throughput

0.667

High

995690

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

966594

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

971763

1433E
14-3-3 protein epsilon

3

6

High-throughput

0.650

High

990478

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

1049540

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

375703

RASK
GTPase KRas

3

15

High-throughput

0.640

High

166796

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

2

7

High-throughput

0.628

High

488130

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

2

7

High-throughput

0.628

High

488184

IFIT1
Antiviral innate immune response effector IFIT1

2

7

High-throughput

0.628

High

1315899

RAB9B
Ras-related protein Rab-9B

3

8

High-throughput

0.609

High

1196883

BCL7A
B-cell CLL/lymphoma 7 protein family member A

3

3

High-throughput

0.604

High

374744

RASH
GTPase HRas

2

12

High-throughput

0.584

High

540552

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

582872

EZRI
Ezrin

2

11

High-throughput

0.584

High

764388

CTNA1
Catenin alpha-1

2

4

Small-scale

0.584

High

975117

ARF6
ADP-ribosylation factor 6

2

1

High-throughput

0.584

High

978149

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

156310

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

2

1

High-throughput

0.574

High

1315889

BCL7C
B-cell CLL/lymphoma 7 protein family member C

2

3

High-throughput

0.574

High

855678

CRK
Adapter molecule crk

2

20

High-throughput

0.571

High

212971

HS12A
Heat shock 70 kDa protein 12A

1

1

High-throughput

0.536

High

930984

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.536

High

993648

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.536

High

1241005

L2GL2
LLGL scribble cell polarity complex component 2

1

3

High-throughput

0.536

High

1311198

RHG12
Rho GTPase-activating protein 12

1

1

High-throughput

0.536

High

374040

RASN
GTPase NRas

2

15

High-throughput

0.533

High

1315900

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

422549

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

347162

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

354359

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

3

High-throughput

0.489

High

987762

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.481

High

126689

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

299280

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

387439

APOE
Apolipoprotein E

1

1

High-throughput

0.479

High

440141

LCK
Tyrosine-protein kinase Lck

1

16

High-throughput

0.479

High

463640

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

464005

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

13

High-throughput

0.479

High

556200

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

581158

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

604084

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

631334

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

648583

FGFR4
Fibroblast growth factor receptor 4

1

18

High-throughput

0.479

High

710354

EPHA2
Ephrin type-A receptor 2

1

16

High-throughput

0.479

High

715667

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

896575

VASP
Vasodilator-stimulated phosphoprotein

1

6

High-throughput

0.479

High

941806

ARL4C
ADP-ribosylation factor-like protein 4C

1

8

High-throughput

0.479

High

953553

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955363

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962252

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962784

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

988514

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1004123

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.479

High

1015586

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1087181

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1151771

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1315887

ARL14
ADP-ribosylation factor-like protein 14

1

2

High-throughput

0.479

High

1315891

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.479

High

1315894

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

1315896

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1315898

E41LA
Band 4.1-like protein 4A

1

8

High-throughput

0.479

High

1315902

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

74544

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.470

High

1315903

RALY
RNA-binding protein Raly

1

4

High-throughput

0.470

High

184308

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

139924

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

154499

CLD4
Claudin-4

1

2

Small-scale

0.437

High

189691

STX7
Syntaxin-7

1

3

High-throughput

0.437

High

210584

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.437

High

226118

STX6
Syntaxin-6

1

4

High-throughput

0.437

High

316911

MTA2
Metastasis-associated protein MTA2

1

4

High-throughput

0.437

High

327348

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

465574

IGF1R
Insulin-like growth factor 1 receptor

1

18

High-throughput

0.437

High

541582

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.437

High

601365

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.437

High

642963

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

710859

EPHB2
Ephrin type-B receptor 2

1

11

High-throughput

0.437

High

845715

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.437

High

936382

AFAD
Afadin

1

14

High-throughput

0.437

High

945039

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.437

High

976400

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.437

High

1034287

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

13

High-throughput

0.437

High

1041164

CAV1
Caveolin-1

1

5

High-throughput

0.437

High

1145001

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.437

High

1159743

OCLN
Occludin

1

4

High-throughput

0.437

High

1187491

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.437

High

1233335

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1270895

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.437

High

1293061

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1315888

PARD3
Partitioning defective 3 homolog

1

5

High-throughput

0.437

High

1315890

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

1315892

SCLT1
Sodium channel and clathrin linker 1

1

14

High-throughput

0.437

High

1315895

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.437

High

1315897

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.437

High

1315901

ARL15
ADP-ribosylation factor-like protein 15

1

3

High-throughput

0.437

High

1315904

ALK
ALK tyrosine kinase receptor

1

16

High-throughput

0.437

High

362316

ABL1
Tyrosine-protein kinase ABL1

1

16

High-throughput

0.408

High

1258500

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.407

High

1315893

FMNL2
Formin-like protein 2

1

0

High-throughput

0.269

Low

238559

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

614707

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025