HitPredict

Interactor 1: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Interactor 2: CACO2 (Q13137)
Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
Gene: CALCOCO2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33545068
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 393 Hs			1 446
+	Hs
		647929 MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72		DLG5_HUMAN (77-439): 7.24e-18: 88.6: 10.03
+	Mm
		682109 AKT1_MOUSE (39-389): 6.73e-121: 360: 19.16		GRDN_MOUSE (115-345): 7.75e-11: 66.7: 21.29
+	Hs
		625530 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		MY18A_HUMAN (127-365): 3.21e-10: 64.8: 15.81
+	Hs
		681840 AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44		DCTN1_HUMAN (104-339): 7.78e-10: 63.2: 10.83
+	Hs
		625177 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		MYH10_HUMAN (60-417): 3.37e-09: 61.3: 12.06
+	Hs
		681881 AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44		GRDN_HUMAN (135-355): 6.19e-09: 60.6: 21.34
+	Hs
		625176 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		MYH9_HUMAN (144-345): 7.94e-09: 60.2: 15.05
+	Hs
		681696 AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44		MYH9_HUMAN (144-345): 7.94e-09: 60.2: 15.05
+	Hs
		528368 CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81		MYH6_HUMAN (94-439): 7.55e-10: 63.6: 12.78
+	Hs
		522604 CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81		MYH7_HUMAN (94-439): 1.46e-09: 62.4: 12.78
+	Hs
		502908 CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81		MYH3_HUMAN (83-355): 2.44e-09: 61.7: 13.36
+	Hs
		960128 CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81		MYH2_HUMAN (77-438): 2.8e-09: 61.7: 11.02
+	Mm
		1130947 AKT2_MOUSE (20-377): 6.02e-112: 337: 20.44		GRDN_MOUSE (115-345): 7.75e-11: 66.7: 21.29
+	Ce
		1089258 AKT1_CAEEL (2-390): 7.29e-111: 336: 18.84		Q20398_CAEEL (78-281): 3.62e-10: 64.4: 10.70
+	Hs
		528369 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		MYH6_HUMAN (94-439): 7.55e-10: 63.6: 12.78
+	Hs
		522609 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		MYH7_HUMAN (94-439): 1.46e-09: 62.4: 12.78
+	Hs
		1023137 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		MYH2_HUMAN (77-438): 2.8e-09: 61.7: 11.02
+	Hs
		502911 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		MYH3_HUMAN (83-355): 2.44e-09: 61.7: 13.36
+	Hs
		522610 STK3_HUMAN (50-369): 2.6e-109: 331: 33.23		MYH7_HUMAN (94-439): 1.46e-09: 62.4: 12.78
+	Hs
		502912 STK3_HUMAN (50-369): 2.6e-109: 331: 33.23		MYH3_HUMAN (83-355): 2.44e-09: 61.7: 13.36