HitPredict

Interactor 1: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Interactor 2: MOB3B (Q86TA1)
MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) (MOB kinase activator-like 2B)
Gene: MOB3B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37536630
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007165 - signal transduction GO:0030295 - protein kinase activator activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 216
+	Hs
		1027394 STK3_HUMAN (50-369): 2.6e-109: 331: 33.23		MOB3B_HUMAN (1-216): 3.2e-122: 346: 100.00
+	Hs
		414970 CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45		MOB3C_HUMAN (1-216): 1.12e-116: 332: 71.76
+	Hs
		1023117 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		MOB1A_HUMAN (13-214): 7.3e-109: 313: 54.46
+	Hs
		1023070 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		MOB1B_HUMAN (13-214): 6.38e-108: 310: 55.45
+	Hs
		1027437 STK3_HUMAN (50-369): 2.6e-109: 331: 33.23		MOB1A_HUMAN (13-214): 7.3e-109: 313: 54.46
+	Hs
		1027391 STK3_HUMAN (50-369): 2.6e-109: 331: 33.23		MOB1B_HUMAN (13-214): 6.38e-108: 310: 55.45
+	Sc
		691068 HOG1_YEAST (66-393): 1.71e-122: 362: 21.15		MOB1_YEAST (10-214): 2.94e-82: 249: 37.38
+	Hs
		972214 MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00		MOB2_HUMAN (18-215): 7.34e-79: 237: 33.33
+	Hs
		414969 CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45		MOB2_HUMAN (18-215): 7.34e-79: 237: 33.33
+	Hs
		1023145 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		PHOCN_HUMAN (10-204): 1.28e-66: 206: 21.72
+	Hs
		1027459 STK3_HUMAN (50-369): 2.6e-109: 331: 33.23		PHOCN_HUMAN (10-204): 1.28e-66: 206: 21.72
+	Dm
		1178607 Q9VEN3_DROME (68-366): 8.77e-104: 321: 32.89		MOB4_DROME (10-204): 4.25e-67: 207: 22.73
+	Hs
		1350192 STK26_HUMAN (65-367): 5.81e-103: 312: 31.80		S4R3N1_HUMAN (10-204): 2.36e-69: 214: 22.22
+	Hs
		131625 STK25_HUMAN (50-367): 4.36e-103: 312: 31.88		PHOCN_HUMAN (10-204): 1.28e-66: 206: 21.72
+	Hs
		1350187 STK26_HUMAN (65-367): 5.81e-103: 312: 31.80		PHOCN_HUMAN (10-204): 1.28e-66: 206: 21.72
+	Hs
		1377585 STK24_HUMAN (65-364): 1.58e-102: 312: 32.12		PHOCN_HUMAN (10-204): 1.28e-66: 206: 21.72