Protein: SRBS1
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)

Gene: SRBS1, SORBS1
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9BX66

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003779 - actin binding
GO:0005158 - insulin receptor binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362364

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.828

High

936438

AFAD
Afadin

2

20

Small-scale

0.806

High

187403

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

Small-scale

0.756

High

154436

SH2B2
SH2B adapter protein 2

2

20

Small-scale

0.754

High

299353

FLOT1
Flotillin-1

5

6

Small-scale

0.710

High

1316702

ABI1
Abl interactor 1

1

20

High-throughput

0.698

High

439842

INSR
Insulin receptor

1

20

Small-scale

0.665

High

613448

VINC
Vinculin

3

14

Small-scale

0.664

High

966825

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

1049731

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

557450

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

728412

AKT1
RAC-alpha serine/threonine-protein kinase

1

12

Small-scale

0.647

High

651428

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.640

High

222190

NCK2
Cytoplasmic protein NCK2

1

18

Small-scale

0.618

High

363810

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

412553

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

648649

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

896876

DYN2
Dynamin-2

1

20

Small-scale

0.618

High

1034332

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1060693

SOS1
Son of sevenless homolog 1

1

20

Small-scale

0.618

High

1353258

PARD3
Partitioning defective 3 homolog

1

17

High-throughput

0.618

High

1416516

ZO2
Tight junction protein 2

1

19

High-throughput

0.618

High

730205

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.611

High

1416514

CASS4
Cas scaffolding protein family member 4

1

20

High-throughput

0.590

High

582937

EZRI
Ezrin

2

17

High-throughput

0.584

High

1356240

FRS2
Fibroblast growth factor receptor substrate 2

1

12

Small-scale

0.573

High

184744

ATX7
Ataxin-7

1

17

Small-scale

0.554

High

1359799

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

2

1

High-throughput

0.553

High

1416518

TEN1
Teneurin-1

1

7

Small-scale

0.552

High

1025416

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.550

High

1029263

INSM1
Insulinoma-associated protein 1

1

0

Small-scale

0.549

High

1059944

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

11

Small-scale

0.545

High

215947

SYNJ1
Synaptojanin-1

1

20

High-throughput

0.541

High

943617

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

9

High-throughput

0.541

High

1308748

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.541

High

530322

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.536

High

549229

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.536

High

1347860

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.536

High

106587

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

785414

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.518

High

1416517

PILRA
Paired immunoglobulin-like type 2 receptor alpha

1

0

High-throughput

0.518

High

1097230

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.515

High

1401840

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.513

High

1416513

SEM6A
Semaphorin-6A

1

7

Small-scale

0.508

High

941254

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

210604

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.479

High

373050

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

474948

VIME
Vimentin

1

19

High-throughput

0.479

High

556317

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

691388

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

730864

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764423

CTNA1
Catenin alpha-1

1

13

High-throughput

0.479

High

765008

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

772201

MSX2
Homeobox protein MSX-2

1

4

High-throughput

0.479

High

833356

PERI
Peripherin

1

19

High-throughput

0.479

High

878550

PAXI
Paxillin

1

15

High-throughput

0.479

High

896628

VASP
Vasodilator-stimulated phosphoprotein

1

20

High-throughput

0.479

High

953069

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.479

High

958184

ARP3
Actin-related protein 3

1

20

High-throughput

0.479

High

971950

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

990681

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

995801

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.479

High

1004185

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.479

High

1022949

EFNB1
Ephrin-B1

1

4

Small-scale

0.479

High

1031527

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.479

High

1101005

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

1105825

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.479

High

1132424

CASP8
Caspase-8

1

4

Small-scale

0.479

High

1140791

KIF14
Kinesin-like protein KIF14

1

19

High-throughput

0.479

High

1153898

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

1156196

ZYX
Zyxin

1

20

High-throughput

0.479

High

1156589

CCDC6
Coiled-coil domain-containing protein 6

1

20

High-throughput

0.479

High

1252215

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1256579

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.479

High

1280915

CNTRL
Centriolin

1

15

High-throughput

0.479

High

1338348

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1350438

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1353136

FBF1
Fas-binding factor 1

1

20

High-throughput

0.479

High

1391169

BICD1
Protein bicaudal D homolog 1

1

19

High-throughput

0.479

High

1411274

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

1416515

LATS2
Serine/threonine-protein kinase LATS2

1

16

High-throughput

0.479

High

1416519

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.479

High

176536

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

843941

HD
Huntingtin

1

5

High-throughput

0.457

High

183964

S22A2
Solute carrier family 22 member 2

1

3

High-throughput

0.445

High

404898

PRIO
Major prion protein

1

1

High-throughput

0.445

High

1398351

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.445

High

1226515

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.437

High

1327175

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1237984

Q6NSK7
RIN3 protein

1

20

High-throughput

0.417

High

479308

P3
P3 protein

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025