HitPredict

Interactor 1: GSTM4 (Q03013)
Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20)
Gene: GSTM4

Interactor 2: Q6FGJ9 (Q6FGJ9)
Glutathione S-transferase (EC 2.5.1.18)
Gene: GSTM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GST_C~GST_C, GST_C~GST_N, GST_N~GST_N
Common GO terms	GO:0004364 - glutathione transferase activity GO:0005829 - cytosol GO:0006749 - glutathione metabolic process GO:0045171 - intercellular bridge
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 225
+	Hs
		597475 GSTM2_HUMAN (1-218): 6.2e-73: 222: 83.03		GSTM3_HUMAN (1-225): 1.3e-76: 232: 100.00
+	Hs
		597498 GSTM4_HUMAN (1-218): 4.77e-72: 219: 100.00		GSTM3_HUMAN (1-225): 1.3e-76: 232: 100.00
+	Hs
		1151008 Q6FGJ9_HUMAN (2-218): 1.27e-70: 216: 72.35		Q6FGJ9_HUMAN (1-225): 1.3e-76: 232: 100.00
+	Hs
		451101 GSTM1_HUMAN (1-218): 1.13e-70: 216: 86.70		GSTM3_HUMAN (1-225): 1.3e-76: 232: 100.00
+	Hs
		597472 GSTM3_HUMAN (2-218): 1.27e-70: 216: 72.35		GSTM3_HUMAN (1-225): 1.3e-76: 232: 100.00
+	Hs
		656873 GSTM2_HUMAN (1-218): 6.2e-73: 222: 83.03		GSTM4_HUMAN (6-222): 1.48e-70: 216: 72.35
+	Hs
		656868 GSTM2_HUMAN (1-218): 6.2e-73: 222: 83.03		GSTM2_HUMAN (6-222): 2.44e-70: 215: 68.66
+	Hs
		451103 GSTM2_HUMAN (1-218): 6.2e-73: 222: 83.03		GSTM1_HUMAN (6-222): 1.41e-69: 214: 72.81
+	Hs
		974233 GSTM4_HUMAN (1-218): 4.77e-72: 219: 100.00		GSTM4_HUMAN (6-222): 1.48e-70: 216: 72.35
+	Rn
		391490 GSTM1_RAT (1-218): 2.4e-70: 215: 73.85		GSTM1_RAT (6-222): 1.1e-69: 214: 67.74
+	Hs
		656870 GSTM2_HUMAN (1-218): 6.2e-73: 222: 83.03		GSTM5_HUMAN (6-222): 7.39e-65: 201: 71.89
+	Hs
		803864 GSTM4_HUMAN (1-218): 4.77e-72: 219: 100.00		GSTM5_HUMAN (6-222): 7.39e-65: 201: 71.89
+	Hs
		451105 GSTM1_HUMAN (1-218): 1.13e-70: 216: 86.70		GSTM5_HUMAN (6-222): 7.39e-65: 201: 71.89
+	Hs
		597486 GSTM3_HUMAN (2-218): 1.27e-70: 216: 72.35		GSTM5_HUMAN (6-222): 7.39e-65: 201: 71.89
+	Hs
		803865 Q6FGJ9_HUMAN (2-218): 1.27e-70: 216: 72.35		GSTM5_HUMAN (6-222): 7.39e-65: 201: 71.89