HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: SSRP1 (Q08945)
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)
Gene: SSRP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 709
+	Hs
		817951 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		996689 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		SSRP1_HUMAN (1-709): 0: 805: 100.00
+	Hs
		996877 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		SSRP1_HUMAN (1-709): 0: 805: 100.00
+	Sc
		810359 SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56		POB3_YEAST (4-504): 0: 541: 29.66
+	Hs
		1080371 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		HM20A_HUMAN (460-709): 1.81e-42: 159: 17.20
+	Mm
		1149777 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		TOX4_MOUSE (496-618): 8.38e-31: 130: 29.03
+	Hs
		1300928 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		CIC_HUMAN (424-708): 7.87e-39: 157: 16.49
+	Hs
		643350 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		HMGB2_HUMAN (540-698): 5.17e-15: 76.3: 23.53
+	Hs
		567706 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		UBF1_HUMAN (416-655): 2.71e-11: 69: 14.52
+	Hs
		818438 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		297441 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		TOX4_HUMAN (484-678): 7.24e-32: 133: 23.86
+	Hs
		331701 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		HMGB1_HUMAN (543-634): 1e-14: 75.5: 34.04
+	Hs
		818819 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		SOX9_HUMAN (447-703): 1.35e-34: 140: 15.15
+	Hs
		152611 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		SOX9_HUMAN (447-703): 1.35e-34: 140: 15.15
+	Hs
		1243843 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		SOX17_HUMAN (475-708): 1.45e-32: 132: 12.61
+	Hs
		152562 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		SOX15_HUMAN (513-702): 2.03e-33: 130: 15.10
+	Hs
		152602 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		SOX5_HUMAN (441-648): 2.62e-30: 129: 19.23
+	Hs
		818266 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		818382 MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		152610 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31