HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: CTR9 (Q6PD62)
RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)
Gene: CTR9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.597

Property	Details
Experiments	20541477
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 1173
+	Hs
		174816 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Hs
		183105 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		183176 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		174922 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Sc
		755792 SET1_YEAST (3466-3969): 6.89e-73: 270: 21.67		CTR9_YEAST (5-982): 1.96e-57: 218: 19.58
+	Hs
		183120 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		1080213 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		TTC28_HUMAN (456-957): 1.51e-19: 97.6: 6.94
+	Hs
		300161 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PRP6_HUMAN (32-285): 7.01e-11: 68.7: 12.02
+	Mm
		1149785 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		PRP6_MOUSE (21-272): 5.67e-10: 66: 11.46
+	Hs
		165599 SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Mm
		1207351 NSD2_MOUSE (3752-3968): 6.91e-55: 215: 27.68		OGT1_MOUSE (10-501): 1.06e-43: 175: 13.19
+	Hs
		183177 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		165600 SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Sc
		542134 SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56		CYC8_YEAST (630-834): 8.66e-10: 65.3: 16.67
+	Hs
		175053 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Hs
		183137 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		150104 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		UTY_HUMAN (27-263): 5.38e-18: 92.2: 11.47
+	Hs
		152556 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		150088 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		UTY_HUMAN (27-263): 5.38e-18: 92.2: 11.47