Protein: SEPT2
Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)

Gene: SEPT2, SEPTIN2
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q15019

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0002036 - regulation of L-glutamate import across plasma membrane
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121177

SEPT6
Septin-6

13

19

Small-scale

0.984

High

1137003

SEPT5
Septin-5

9

19

Small-scale

0.979

High

1136967

SEPT7
Septin-7

8

19

Small-scale

0.968

High

1137019

SEP11
Septin-11

8

19

High-throughput

0.966

High

1137025

SEPT9
Septin-9

7

19

Small-scale

0.965

High

1136990

SEPT8
Septin-8

5

19

High-throughput

0.927

High

1137022

SEP10
Septin-10

5

19

High-throughput

0.927

High

1137024

SEPT3
Neuronal-specific septin-3

5

19

High-throughput

0.925

High

1136983

SEP12
Septin-12

4

19

Small-scale

0.899

High

1136987

SEPT1
Septin-1

3

19

High-throughput

0.861

High

210494

SEPT4
Septin-4

2

20

High-throughput

0.811

High

1136976

SEP14
Septin-14

2

19

Small-scale

0.783

High

1136962

SEPT2
Septin-2

1

19

Small-scale

0.692

High

1137009

BORG4
Cdc42 effector protein 4

3

14

High-throughput

0.667

High

890653

RGS3
Regulator of G-protein signaling 3

3

9

High-throughput

0.662

High

1137018

ANLN
Anillin

3

11

High-throughput

0.656

High

241714

PRKN
E3 ubiquitin-protein ligase parkin

3

11

High-throughput

0.640

High

535075

BIP
Endoplasmic reticulum chaperone BiP

2

8

High-throughput

0.611

High

1136966

EZH2
Histone-lysine N-methyltransferase EZH2

2

4

High-throughput

0.611

High

1137027

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

2

7

High-throughput

0.606

High

955181

CDC42
Cell division control protein 42 homolog

2

13

High-throughput

0.595

High

1136993

SH3K1
SH3 domain-containing kinase-binding protein 1

2

7

Small-scale

0.595

High

791391

SYUA
Alpha-synuclein

2

7

Small-scale

0.586

High

1067345

EP300
Histone acetyltransferase p300

2

6

High-throughput

0.584

High

1136984

TBC21
TBC1 domain family member 21

2

0

High-throughput

0.580

High

1136986

VA0D2
V-type proton ATPase subunit d 2

2

0

High-throughput

0.580

High

1137005

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.580

High

914613

RM12
Large ribosomal subunit protein bL12m

2

9

High-throughput

0.574

High

1136964

RBP1
RalA-binding protein 1

2

4

High-throughput

0.571

High

997724

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.550

High

249138

DSCAM
Cell adhesion molecule DSCAM

1

1

High-throughput

0.541

High

899909

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

158206

COPE
Coatomer subunit epsilon

1

4

High-throughput

0.536

High

389369

FINC
Fibronectin

1

4

High-throughput

0.536

High

484539

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1136981

WDFY1
WD repeat and FYVE domain-containing protein 1

1

6

High-throughput

0.536

High

1136997

SCYL1
N-terminal kinase-like protein

1

3

High-throughput

0.536

High

1136999

ACAP3
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

1

10

High-throughput

0.536

High

1137001

TGS1
Trimethylguanosine synthase

1

3

High-throughput

0.536

High

1137008

CPVL
Probable serine carboxypeptidase CPVL

1

4

High-throughput

0.536

High

1137010

AMPB
Aminopeptidase B

1

1

High-throughput

0.536

High

1137020

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

1

1

High-throughput

0.536

High

1137014

PKHF2
Pleckstrin homology domain-containing family F member 2

1

6

High-throughput

0.523

High

1136963

DAZP2
DAZ-associated protein 2

1

0

High-throughput

0.518

High

160709

TOR1A
Torsin-1A

1

1

High-throughput

0.515

High

422121

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

1137030

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.515

High

464156

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.513

High

1136971

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

1136992

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1137004

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

839274

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.508

High

396134

ESR1
Estrogen receptor

1

12

Small-scale

0.501

High

773504

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.489

High

599592

STMN1
Stathmin

1

0

High-throughput

0.486

High

172827

XPO1
Exportin-1

1

13

High-throughput

0.479

High

247915

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

299199

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

1137031

SRRM2
Serine/arginine repetitive matrix protein 2

1

4

High-throughput

0.479

High

318774

RHBT1
Rho-related BTB domain-containing protein 1

1

10

High-throughput

0.479

High

345839

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

411953

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

425508

ISG15
Ubiquitin-like protein ISG15

1

7

Small-scale

0.479

High

556088

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

558146

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

588729

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

605079

JUND
Transcription factor JunD

1

1

High-throughput

0.479

High

606783

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

642880

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

659481

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

695491

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

714131

PML
Protein PML

1

5

High-throughput

0.479

High

715589

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

731308

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

768226

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

799129

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

830758

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

862146

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

872343

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

964956

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

975039

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

978015

RHOB
Rho-related GTP-binding protein RhoB

1

15

High-throughput

0.479

High

1008730

RED1
Double-stranded RNA-specific editase 1

1

6

High-throughput

0.479

High

1045303

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1050424

UBE3A
Ubiquitin-protein ligase E3A

1

3

High-throughput

0.479

High

1097194

PAK2
Serine/threonine-protein kinase PAK 2

1

2

High-throughput

0.479

High

1106883

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1121214

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

1122484

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1136970

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1136972

RHGBA
Rho GTPase-activating protein 11A

1

1

High-throughput

0.479

High

1136974

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

1136975

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1136977

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.479

High

1136978

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1136979

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1136980

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1136982

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.479

High

1136988

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1136989

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1136991

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1137000

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

1137006

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1137011

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1137017

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1137021

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

1137023

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1137029

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1137015

JUPI2
Jupiter microtubule associated homolog 2

1

0

High-throughput

0.460

High

380036

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

699752

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.458

High

764334

CTNA1
Catenin alpha-1

1

0

Small-scale

0.458

High

822668

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

1136965

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

1137007

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1137013

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1136995

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.457

High

429913

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

529818

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

1015447

RHOG
Rho-related GTP-binding protein RhoG

1

11

Small-scale

0.445

High

1130252

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

1136968

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1136996

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

1136998

CEP63
Centrosomal protein of 63 kDa

1

6

High-throughput

0.445

High

1137012

VIAAT
Vesicular inhibitory amino acid transporter

1

4

High-throughput

0.445

High

1137002

CRML
Protein cramped-like

1

0

High-throughput

0.438

High

105957

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

353336

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

1136969

DCA15
DDB1- and CUL4-associated factor 15

1

3

High-throughput

0.437

High

1136985

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

1

High-throughput

0.437

High

1137028

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.437

High

886872

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

653323

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

1136973

SFTA2
Surfactant-associated protein 2

1

0

High-throughput

0.279

Low

1136994

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.279

Low

1137016

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.265

Low

377212

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

1137026

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025