HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	11313484, 18676843, 20541251
Identification Methods	two hybrid, affinity chromatography technology, x-ray crystallography, nuclear magnetic resonance, molecular sieving, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 301
+	Dm
		594808 TRX_DROME (3633-3969): 3.49e-71: 270: 43.54		PPIE_DROME (1-300): 2.1e-104: 308: 64.67
+	Hs
		614333 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PPIB_HUMAN (143-300): 5.03e-63: 199: 58.49
+	Hs
		923694 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Sc
		540574 SET1_YEAST (3466-3969): 6.89e-73: 270: 21.67		CYPH_YEAST (139-300): 3.45e-63: 198: 60.49
+	Hs
		331776 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Hs
		152624 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46