HitPredict

Interactor 1: RS6 (P62753)
Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)
Gene: RPS6

Interactor 2: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21423205
Identification Methods	protein kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 249 Hs			1 735
+	Dm
		710936 RS6_DROME (1-238): 3.32e-103: 301: 76.57		Q24496_DROME (2-729): 0: 710: 50.39
+	Dm
		710958 RS6_DROME (1-238): 3.32e-103: 301: 76.57		Q9VR61_DROME (2-729): 0: 710: 50.39
+	Hs
		979322 RS6_HUMAN (1-249): 9.66e-112: 322: 100.00		KS6B2_HUMAN (418-734): 2.4e-114: 355: 27.46
+	Hs
		658585 RS6_HUMAN (1-249): 9.66e-112: 322: 100.00		KS6B1_HUMAN (393-727): 4.8e-112: 351: 24.58
+	Mm
		979400 RS6_MOUSE (1-249): 9.66e-112: 322: 100.00		KS6B1_MOUSE (393-727): 5.07e-112: 351: 24.58
+	Hs
		605630 RS6_HUMAN (1-249): 9.66e-112: 322: 100.00		KAPCA_HUMAN (406-704): 2.17e-113: 348: 30.03
+	Hs
		651639 RS6_HUMAN (1-249): 9.66e-112: 322: 100.00		KAPCB_HUMAN (406-704): 5.56e-113: 347: 30.03
+	Hs
		978953 RS6_HUMAN (1-249): 9.66e-112: 322: 100.00		KS6A2_HUMAN (2-323): 4.03e-98: 320: 23.65
+	Sp
		1421403 RS6B_SCHPO (1-238): 1.84e-105: 306: 68.75		GAD8_SCHPO (416-679): 2.67e-27: 119: 30.04
+	Sp
		1085053 RS6B_SCHPO (1-238): 1.84e-105: 306: 68.75		PSK1_SCHPO (424-666): 1.27e-22: 103: 30.28