HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 2514
+	Hs
		261475 TLE3_HUMAN (1-772): 0: 583: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		1346974 NLE1_HUMAN (690-769): 9.94e-22: 101: 22.22		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		980914 TLE3_HUMAN (1-772): 0: 583: 100.00		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Xl
		1093463 TB1RA_XENLA (560-772): 3.08e-47: 177: 15.15		Q1W3Z6_XENLA (4-2514): 7.45e-150: 523: 51.60
+	Hs
		980850 TLE3_HUMAN (1-772): 0: 583: 100.00		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		980847 TLE3_HUMAN (1-772): 0: 583: 100.00		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		980825 TLE3_HUMAN (1-772): 0: 583: 100.00		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61
+	Hs
		261584 TBL1R_HUMAN (571-771): 3.06e-46: 174: 15.07		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Xl
		1186358 TB1RA_XENLA (560-772): 3.08e-47: 177: 15.15		NCOR1_XENLA (1-2514): 7.28e-122: 434: 32.87
+	Hs
		261563 SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Mm
		1206586 TBL1R_MOUSE (560-771): 3.94e-46: 174: 15.28		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Mm
		1206786 TBL1X_MOUSE (571-771): 5.49e-46: 174: 16.51		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Hs
		1346970 NLE1_HUMAN (690-769): 9.94e-22: 101: 22.22		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		793042 LIS1_HUMAN (686-769): 6.84e-19: 91.8: 22.35		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		903450 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		903374 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93
+	Hs
		1302927 NLE1_HUMAN (690-769): 9.94e-22: 101: 22.22		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		1288394 SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		1288258 SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		1264784 SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61