HitPredict

Interactor 1: CDC42 (Q05062)
Cell division control protein 42 homolog (CDC42Ce)
Gene: cdc-42

Interactor 2: TOCA2 (Q9XUS7)
Transducer of Cdc42-dependent actin assembly protein 2 homolog
Gene: toca-2

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25775511
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0055037 - recycling endosome GO:2000370 - positive regulation of clathrin-dependent endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Ce			1 610
+	Hs
		564653 RHOQ_HUMAN (4-187): 3.27e-91: 266: 67.94		FNBP1_HUMAN (9-608): 2.63e-74: 251: 20.76
+	Hs
		564542 RHOQ_HUMAN (4-187): 3.27e-91: 266: 67.94		CIP4_HUMAN (9-608): 4.6e-73: 247: 18.50
+	Hs
		1132435 RHOJ_HUMAN (2-189): 5.52e-84: 248: 63.30		FBP1L_HUMAN (9-608): 3.32e-77: 258: 18.91
+	Hs
		1301540 RHOJ_HUMAN (2-189): 5.52e-84: 248: 63.30		FNBP1_HUMAN (9-608): 2.63e-74: 251: 20.76
+	Hs
		925339 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		FBP1L_HUMAN (9-608): 3.32e-77: 258: 18.91
+	Hs
		1075815 RHOJ_HUMAN (2-189): 5.52e-84: 248: 63.30		CIP4_HUMAN (9-608): 4.6e-73: 247: 18.50
+	Hs
		925540 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		FNBP1_HUMAN (9-608): 2.63e-74: 251: 20.76
+	Hs
		564496 RHOQ_HUMAN (4-187): 3.27e-91: 266: 67.94		FCHO2_HUMAN (3-541): 7.14e-55: 201: 12.32
+	Hs
		253311 RHOQ_HUMAN (4-187): 3.27e-91: 266: 67.94		SRGP2_HUMAN (9-451): 9.03e-54: 200: 14.75
+	Hs
		925414 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		NOSTN_HUMAN (14-607): 2.56e-65: 224: 14.57
+	Hs
		1001594 RHOJ_HUMAN (2-189): 5.52e-84: 248: 63.30		FCHO2_HUMAN (3-541): 7.14e-55: 201: 12.32
+	Hs
		200213 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		SRGP3_HUMAN (9-463): 5.08e-56: 207: 15.71
+	Hs
		925230 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		FCHO2_HUMAN (3-541): 7.14e-55: 201: 12.32
+	Hs
		925395 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		SRGP1_HUMAN (9-458): 2.21e-54: 201: 15.88
+	Hs
		253337 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		SRGP2_HUMAN (9-451): 9.03e-54: 200: 14.75
+	Hs
		925192 RAC1_HUMAN (1-191): 2.97e-81: 241: 69.11		RHG04_HUMAN (8-478): 1.78e-47: 181: 12.65
+	Hs
		564738 RHOQ_HUMAN (4-187): 3.27e-91: 266: 67.94		PACN2_HUMAN (145-610): 1.51e-18: 91.1: 9.98
+	Hs
		564730 RHOQ_HUMAN (4-187): 3.27e-91: 266: 67.94		PACN3_HUMAN (249-607): 1.68e-17: 87: 13.54
+	Hs
		1330988 RHOJ_HUMAN (2-189): 5.52e-84: 248: 63.30		PACN2_HUMAN (145-610): 1.51e-18: 91.1: 9.98
+	Hs
		1330981 RHOJ_HUMAN (2-189): 5.52e-84: 248: 63.30		PACN3_HUMAN (249-607): 1.68e-17: 87: 13.54