HitPredict

Interactor 1: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Interactor 2: PACN1 (Q9BY11)
Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)
Gene: PACSIN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	15252009, 11082044
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0045202 - synapse GO:0098684 - photoreceptor ribbon synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 864 Hs			1 444
+	Rn
		599414 DYN1_RAT (1-864): 0: 1081: 98.03		PACN1_RAT (1-444): 1.89e-92: 288: 95.27
+	Mm
		760451 DYN1_MOUSE (1-845): 0: 1081: 99.65		PACN1_MOUSE (1-444): 2.72e-92: 287: 95.05
+	Hs
		983417 DYN1_HUMAN (1-864): 0: 1087: 100.00		PACN2_HUMAN (1-444): 2.16e-80: 258: 61.32
+	Hs
		983416 DYN1_HUMAN (1-864): 0: 1087: 100.00		PACN3_HUMAN (7-444): 2.52e-76: 246: 49.32
+	Hs
		840812 DYN2_HUMAN (1-860): 0: 1021: 78.91		PACN1_HUMAN (1-444): 6.15e-95: 294: 100.00
+	Mm
		760475 DYN2_MOUSE (1-860): 0: 1022: 79.13		PACN1_MOUSE (1-444): 2.72e-92: 287: 95.05
+	Mm
		760487 DYN2_MOUSE (1-860): 0: 1022: 79.13		PACN2_MOUSE (1-444): 7.75e-83: 265: 61.93
+	Hs
		983392 DYN1_HUMAN (1-864): 0: 1087: 100.00		NOSTN_HUMAN (25-444): 2.46e-56: 195: 16.77
+	Mm
		760485 DYN2_MOUSE (1-860): 0: 1022: 79.13		PACN3_MOUSE (7-444): 3.76e-79: 253: 49.54
+	Hs
		840860 DYN2_HUMAN (1-860): 0: 1021: 78.91		PACN3_HUMAN (7-444): 2.52e-76: 246: 49.32
+	Hs
		207784 DYN2_HUMAN (1-860): 0: 1021: 78.91		PPIP1_HUMAN (10-444): 1.02e-62: 210: 19.77
+	Hs
		840700 DYN2_HUMAN (1-860): 0: 1021: 78.91		CIP4_HUMAN (19-391): 3.5e-42: 159: 15.12
+	Hs
		983379 DYN1_HUMAN (1-864): 0: 1087: 100.00		ITSN1_HUMAN (367-442): 5.46e-13: 73.6: 31.58
+	Rn
		599413 DYN1_RAT (1-864): 0: 1081: 98.03		ITSN1_RAT (367-442): 1.27e-12: 72.4: 32.90
+	Mm
		760469 DYN1_MOUSE (1-845): 0: 1081: 99.65		ITSN1_MOUSE (367-442): 1.31e-12: 72: 32.90
+	Hs
		983403 DYN1_HUMAN (1-864): 0: 1087: 100.00		FNBP1_HUMAN (224-443): 9.17e-09: 59.7: 13.16
+	Hs
		840702 DYN2_HUMAN (1-860): 0: 1021: 78.91		ITSN1_HUMAN (367-442): 5.46e-13: 73.6: 31.58
+	Mm
		760488 DYN2_MOUSE (1-860): 0: 1022: 79.13		ITSN1_MOUSE (367-442): 1.31e-12: 72: 32.90
+	Hs
		840723 DYN2_HUMAN (1-860): 0: 1021: 78.91		FBP1L_HUMAN (244-443): 8.15e-10: 62.8: 13.81
+	Hs
		840798 DYN2_HUMAN (1-860): 0: 1021: 78.91		FNBP1_HUMAN (224-443): 9.17e-09: 59.7: 13.16