Protein: M3K2
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)

Gene: M3K2, MAP3K2
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9Y2U5

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1097125

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

9

16

Small-scale

0.978

High

1490929

M3K2
Mitogen-activated protein kinase kinase kinase 2

5

15

Small-scale

0.924

High

1022813

XIAP
E3 ubiquitin-protein ligase XIAP

2

10

Small-scale

0.849

High

853914

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

3

18

Small-scale

0.840

High

1407267

M3K3
Mitogen-activated protein kinase kinase kinase 3

3

16

Small-scale

0.834

High

1144332

STK38
Serine/threonine-protein kinase 38

3

11

Small-scale

0.827

High

1097177

MK07
Mitogen-activated protein kinase 7

2

20

Small-scale

0.789

High

162061

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

16

Small-scale

0.768

High

730381

1433B
14-3-3 protein beta/alpha

11

20

High-throughput

0.757

High

508867

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

13

Small-scale

0.754

High

967050

1433G
14-3-3 protein gamma

8

20

High-throughput

0.753

High

972164

1433E
14-3-3 protein epsilon

7

15

Small-scale

0.750

High

691563

1433T
14-3-3 protein theta

7

20

High-throughput

0.746

High

990900

1433Z
14-3-3 protein zeta/delta

6

20

High-throughput

0.735

High

1049933

1433F
14-3-3 protein eta

6

20

High-throughput

0.732

High

349299

LATS1
Serine/threonine-protein kinase LATS1

1

12

Small-scale

0.724

High

466718

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.724

High

692166

MARK3
MAP/microtubule affinity-regulating kinase 3

1

13

High-throughput

0.691

High

920385

PLK1
Serine/threonine-protein kinase PLK1

1

16

High-throughput

0.691

High

1108303

SQSTM
Sequestosome-1

1

4

High-throughput

0.691

High

1110324

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

4

High-throughput

0.691

High

730976

1433S
14-3-3 protein sigma

3

20

High-throughput

0.662

High

858736

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

Small-scale

0.647

High

1107506

BIRC2
Baculoviral IAP repeat-containing protein 2

1

10

Small-scale

0.647

High

1439017

SMUF1
E3 ubiquitin-protein ligase SMURF1

3

10

Small-scale

0.646

High

861850

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

10

High-throughput

0.619

High

181196

AXIN1
Axin-1

1

6

Small-scale

0.618

High

214079

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.618

High

243344

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.618

High

462070

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468942

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

507430

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

13

High-throughput

0.618

High

853760

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.618

High

891902

GSK3B
Glycogen synthase kinase-3 beta

1

17

Small-scale

0.618

High

987274

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

12

High-throughput

0.618

High

987505

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

11

High-throughput

0.618

High

1448722

LATS2
Serine/threonine-protein kinase LATS2

1

13

Small-scale

0.618

High

1490726

ST38L
Serine/threonine-protein kinase 38-like

1

11

Small-scale

0.618

High

1490911

AXIN2
Axin-2

1

6

Small-scale

0.618

High

1246180

TRAF7
E3 ubiquitin-protein ligase TRAF7

3

5

High-throughput

0.609

High

1435633

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

Small-scale

0.598

High

1462281

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

Small-scale

0.596

High

1400054

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

10

Small-scale

0.595

High

765143

CTNB1
Catenin beta-1

1

2

Small-scale

0.578

High

117120

J3QRB6
mitogen-activated protein kinase kinase kinase

1

16

High-throughput

0.575

High

862572

YAP1
Transcriptional coactivator YAP1

1

15

Small-scale

0.561

High

1490933

NEMO
NF-kappa-B essential modulator

1

9

High-throughput

0.561

High

1445801

SH22A
SH2 domain-containing protein 2A

1

16

Small-scale

0.552

High

217546

E41L2
Band 4.1-like protein 2

1

1

High-throughput

0.536

High

224833

ACTN4
Alpha-actinin-4

1

3

High-throughput

0.536

High

326109

UBR5
E3 ubiquitin-protein ligase UBR5

1

14

High-throughput

0.536

High

670040

MCM3
DNA replication licensing factor MCM3

1

4

High-throughput

0.536

High

1336336

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.536

High

1490930

SGT1
Protein SGT1 homolog

1

6

High-throughput

0.536

High

637802

FLNA
Filamin-A

1

10

High-throughput

0.515

High

298122

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

725818

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

1490660

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

288546

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.501

High

1394640

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

11

High-throughput

0.501

High

1100743

STX3
Syntaxin-3

1

1

High-throughput

0.489

High

1461771

COR1C
Coronin-1C

1

4

High-throughput

0.489

High

340691

STABP
STAM-binding protein

1

0

Small-scale

0.480

High

623600

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.479

High

1155927

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1400881

RAB3I
Rab-3A-interacting protein

1

2

High-throughput

0.479

High

1409808

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

Small-scale

0.479

High

1429026

WWTR1
WW domain-containing transcription regulator protein 1

1

15

Small-scale

0.479

High

1490642

FBW1A
F-box/WD repeat-containing protein 1A

1

7

Small-scale

0.479

High

1490931

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1361188

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.460

High

1258626

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

9

High-throughput

0.445

High

1450433

FBX28
F-box only protein 28

1

2

High-throughput

0.407

High

1490932

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025