HitPredict

Interactor 1: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, luminescence based mammalian interactome mapping, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001525 - angiogenesis GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 389
+	Mm
		403419 FAK1_MOUSE (1-1052): 0: 1121: 97.34		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Hs
		454825 FAK1_HUMAN (1-1052): 0: 1127: 100.00		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		522927 FAK1_HUMAN (1-1052): 0: 1127: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		433716 FAK1_HUMAN (1-1052): 0: 1127: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		924501 FAK1_HUMAN (1-1052): 0: 1127: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433329 FAK1_HUMAN (1-1052): 0: 1127: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		412143 FAK1_HUMAN (1-1052): 0: 1127: 100.00		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		442812 FAK1_HUMAN (1-1052): 0: 1127: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		411688 FAK1_HUMAN (1-1052): 0: 1127: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Mm
		710138 FAK1_MOUSE (1-1052): 0: 1121: 97.34		GRB2_MOUSE (56-256): 2.26e-50: 170: 15.71
+	Hs
		802571 FAK1_HUMAN (1-1052): 0: 1127: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Mm
		710126 FAK1_MOUSE (1-1052): 0: 1121: 97.34		FYN_MOUSE (38-280): 1.65e-45: 165: 15.67
+	Gg
		337665 FAK1_CHICK (1-1052): 0: 1111: 93.74		SRC_CHICK (21-280): 3.33e-48: 173: 18.09
+	Hs
		796549 FAK1_HUMAN (1-1052): 0: 1127: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Mm
		403463 FAK2_MOUSE (35-1043): 0: 861: 45.58		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Rn
		936859 FAK2_RAT (35-1043): 0: 866: 44.78		SRC_RAT (5-280): 5.38e-50: 177: 17.45
+	Hs
		522984 FAK2_HUMAN (35-1043): 0: 852: 44.78		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		433760 FAK2_HUMAN (35-1043): 0: 852: 44.78		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		412191 FAK2_HUMAN (35-1043): 0: 852: 44.78		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		411720 FAK2_HUMAN (35-1043): 0: 852: 44.78		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31